摘要
目的:探究寿胎丸加味联合黄体酮及低分子肝素治疗复发性流产的临床疗效。方法:选取2017年1月至2018年12月上海中医药大学附属曙光医院收治的符合纳入条件的复发性流产患者72例作为研究对象,随机分为观察组(n=37)和对照组(n=35)。观察组给予寿胎丸加味+低分子肝素+黄体酮治疗,对照组给予低分子肝素+黄体酮治疗,2组患者均同时治疗2周。观察2组患者治疗前、完成治疗后子宫动脉阻力指标如子宫动脉阻力指数(RI)、收缩期峰值血流/舒张期末流速比(S/D)变化并比较;观察2组患者治疗前、治疗后D-二聚体(D-D)、血小板聚集率、的变化并比较;观察2组患者治疗前、治疗后在中医证候积分如腰膝酸软、头晕耳鸣、畏寒肢冷、面色晦暗、夜尿频多、舌淡紫暗或瘀斑的变化并比较;完成治疗后进行安全性评价。结果:1)治疗前2组患者RI、S/D比较,差异无统计学意义(P>0.05),治疗后2组患者的RI、S/D水平较治疗前均显著下降(P<0.05),2组患者比较差异无统计学意义(P>0.05)。2)治疗前2组患者的D-D、血小板聚集率比较,差异无统计学意义(P>0.05),治疗后2组患者的D-D、血小板聚集率较治疗前均显著下降(P<0.05),2组患者比较差异无统计学意义(P>0.05)。3)治疗前2组患者腰膝酸软、头晕耳鸣、畏寒肢冷、面色晦暗夜尿频多、舌淡紫暗或瘀斑的积分比较,差异无统计学意义(P>0.05),治疗后观察组的中医证候积分均低于对照组(P<0.05),2组患者比较差异有统计学意义(P<0.05)。4)观察组在胃肠道反应、皮疹、荨麻疹的发生率低于对照组,差异有统计学意义(P<0.05),而在皮下血肿、牙龈出血方面比较,差异无统计学意义(P>0.05)。结论:寿胎丸加味联合黄体酮及低分子肝素能通过降低RSA子宫动脉阻力,改善胚胎血液循环,从而降低流产的发生,改善妊娠结局,且安全性。
Objective: To explore the clinical effects of Shoutaiwan Pill combined with progesterone and low molecular weight heparin in the treatment of recurrent abortion. Methods: A total of 72 patients with recurrent abortion admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2017 to December 2018 were randomly divided into an observation group(37 cases)and control group(35 cases).The observation group was treated with Shoutaiwan Pill,low molecular weight heparin and progesterone,while the control group was treated with low molecular weight heparin and progesterone.Both groups were treated for 2 weeks at the same time.The changes of uterine artery resistance indexes such as uterine artery resistance index(RI)and systolic peak blood flow/end diastolic velocity ratio(S/D)before and after treatment were observed and compared;the changes of D-dimer(D-D),platelet aggregation rate before and after treatment were observed and compared between the 2 groups;the scores of TCM syndromes such as soreness and weakness of waist and knees,dizziness,tinnitus,cold limbs,dark complexion,frequent nocturnal urination,pale purple tongue or ecchymosis before and after treatment were observed and compared between the 2 groups.The safety was evaluated after treatment. Results: The RI and S/D levels of the 2 groups before treatment were compared,and the difference was not statistically significant( P >0.05).After treatment,the RI and S/D levels of the 2 groups were significantly decreased than those before treatment( P <0.05),and there was no significant difference between the 2 groups( P > 0.05).(2)Before treatment,the D-D and platelet aggregation rates of the two groups were compared,and there was no statistically significant difference( P >0.05).After treatment,the D-D and platelet aggregation rates of the 2 groups decreased significantly( P <0.05),but there was no significant difference between the 2 groups( P >0.05).(3)Before treatment,the scores of lumbar and knee weakness,dizziness
作者
杨碧蓉
周华
Yang Birong;Zhou Hua(Department of Gynecology,Shuguang Hospital Affiliated to Shanghai University of TraditionalChinese Medicine,Shanghai 201203,China)
出处
《世界中医药》
CAS
2019年第6期1502-1506,共5页
World Chinese Medicine
基金
上海市海派中医流派传承人才培养项目继承人(沪卫计中发办LPRC2017032)
关键词
寿胎丸
黄体酮
低分子肝素
复发性流产
子宫动脉阻力
中医证候积分
凝血功能
安全性
Shoutai Pills
Progesterone
Low molecular weight heparin
Recurrent abortion
Uterine artery resistance
TCM syndrome integral
Coagulation function
Safety
