摘要
目的探讨血脂及血清相关炎性因子水平变化在妊娠期高血压疾病(HDP)发展中的临床意义。方法选择2017年1月至2018年6月产科诊断为HDP的105例孕妇为观察组,根据病情的程度不同分将其为妊娠期高血压组(38例),子痫前期组(35例)及重度子痫前期组(32例),将同期来产科就诊的无妊娠合并症的40例正常妊娠孕妇设为正常组。比较各组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、白介素-2(IL-2)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)及C-反应蛋白(CRP)水平。结果妊娠期高血压组、子痫前期组、重度子痫前期组的TC、TG、LDL-C水平高于正常组,HDL-C水平低于正常组(P<0.05);重度子痫前期组的TC、TG、LDL-C水平高于妊娠期高血压组及子痫前期组,HDL-C水平低于妊娠期高血压组及子痫前期组(P<0.05)。妊娠期高血压组、子痫前期组、重度子痫前期组的IL-2、TNF-α、CRP水平高于正常组,IL-10水平低于正常组(P<0.05);随着疾病的加重,IL-2、TNF-α、CRP水平逐渐升高,IL-10水平逐渐降低。结论HDP孕妇存在脂代谢紊乱,炎性因子分泌异常,孕期密切监测孕妇血脂及炎性因子水平,可预测疾病进展的程度,对改善母婴预后具有积极意义。
Objective To explore the clinical significance of changes of the levels of serum lipid and serum related inflammatory factors in the development of hypertensive disorders of pregnancy (HDP). Methods A total of 105 pregnant women diagnosed as HDP in obstetrics department from January 2017 to June 2018 were selected as observation group. According to the degree of the disease, the patients were divided into hypertensive pregnancy group (38 cases), preeclampsia group (35 cases) and severe preeclampsia group (32 cases). Forty normal pregnant women without pregnancy complications who visited to obstetrics department in the same period were set as normal group. The serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), interleukin-2 (IL-2), interleukin-10 (IL-10), tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP) in each group were compared. Results The levels of TC, TG and LDL-C in the hypertensive pregnancy group, preeclampsia group and severe preeclampsia group were higher than those in the normal group, while HDL-C levels were lower than those in the normal group (P<0.05). The levels of TC, TG and LDL-C in the severe preeclampsia group were higher than those in the pregnancy hypertension group and preeclampsia group, and HDL-C levels were lower than those in the pregnancy hypertension group and preeclampsia group (P<0.05). The levels of IL-2, TNF-α and CRP in the hypertensive pregnancy group, preeclampsia group and severe preeclampsia group were higher than those in the normal group, and the levels of IL-10 were lower than those in the normal group (P<0.05). With the aggravation of the disease, the levels of IL-2, TNF-α and CRP gradually increased, while the level of IL-10 gradually decreased. Conclusion Pregnant women with HDP have disorders of lipid metabolism and abnormal secretion of inflammatory factors. Closely monitoring of maternal lipid and inflammatory factors during pregnancy can predict the extent of disease progression
作者
武妍
武婧
WU Yan;WU Jing(Jingbian County Maternal and Child Health Hospital,Yulin 718500;the People's Hospital of Jingbian County,Yulin 718500,China)
出处
《临床医学研究与实践》
2019年第18期86-87,92,共3页
Clinical Research and Practice
关键词
妊娠期高血压疾病
血脂
炎性因子
hypertensive disorders of pregnancy
blood lipid
inflammatory factors
