摘要
目的分析非HBV(乙型肝炎病毒)相关性肝病肝移植术后新发HBV感染的临床表现和预防建议。方法选取本院2016年1月~2019年2月间收治的97例非HBV相关性肝病肝移植术后患者为本研究临床资料,采用统计学分析非HBV相关性肝病肝移植术前以及术后不同原发病(先天性胆道闭锁、自身免疫性肝病、酒精性肝硬化或丙型肝炎硬化等)受体肝移植后乙肝表面抗原状况、受体抗HBs阳性与肝移植后乙型肝炎新发关系、受体抗HBc阴性与肝移植后乙型肝炎新发关系等。结果①不同原发病(先天性胆道闭锁、自身免疫性肝病、酒精性肝硬化或丙型肝炎硬化等)患者的术后乙肝表面抗原阳性率比较,差异有统计学意义(P <0.05);②受体抗HBs阴性患者与受体抗HBs阳性患者术后乙肝表面抗原阳性率比较,差异无统计学意义(P> 0.05);③受体抗HBc阴性患者术后乙肝表面抗原阳性率显著高于受体抗HBc阳性患者(P <0.05)。结论非HBV(乙型肝炎病毒)相关性肝病肝移植术后存在新发乙型肝炎病毒风险,临床需加强预防手段。
Objective To analyze the clinical manifestations and prevention suggestions of new HBV infection after liver transplantation for non-HBV (hepatitis B virus) related liver diseases. Methods 97 patients with non-HBV related liver diseases admitted to our hospital from January 2016 to February 2019 after liver transplantation were selected as clinical data for this study. Statistical analysis was conducted on the hepatitis B surface antigen status, the new relationship between receptor anti-HBs positive and hepatitis B after liver transplantation, and the new relationship between receptor anti-HBc negative and hepatitis B after liver transplantation in different primary diseases (congenital biliary atresia, autoimmune liver disease, alcoholic liver cirrhosis or hepatitis C sclerosis, etc.) before and after liver transplantation. Results ① the positive rate of hepatitis B surface antigen in patients with different primary diseases (congenital biliary atresia, autoimmune liver disease, alcoholic liver cirrhosis or hepatitis c sclerosis, etc.) was statistically significant (P < 0.05).② there was no significant difference in the positive rate of hepatitis B surface antigen between patients with negative receptor anti-HBs and patients with positive receptor anti-HBs (P > 0.05);③ the positive rate of hepatitis B surface antigen in patients with negative receptor anti-HBc was significantly higher than that in patients with positive receptor anti-HBc (P < 0.05). Conclusion There is a risk of new hepatitis B virus after liver transplantation for non-HBV (hepatitis B virus)-related liver diseases, and prevention measures should be strengthened clinically.
作者
孙一博
SUN Yi-bo(Department of Organ Transplantation, Zhengzhou People's Hospital, Zhengzhou, Henan, 450000, China)
出处
《临床研究》
2019年第7期31-33,共3页
Clinical Research
关键词
乙型肝炎病毒
相关性肝病
肝移植
新发HBV
感染
hepatitis B virus
related liver diseases
liver transplantation
newly diagnosed HBV infection
