摘要
适宜的运动可显著降低心血管疾病的发生率,死亡率,并有效改善心血管患者的预后,是心血管疾病有效的预防和辅助治疗方法。运动可以降低炎症反应,改善血管内皮状况,改善代谢和能量利用等,其对心血管的保护作用涉及多种机制。本文综述近年来运动对降低胰岛素抵抗,改善血管内皮状况,改善心肌线粒体功能和激活miRNA这4个方面内容,阐述了运动对心血管保护作用的机制及相关研究进展。
Appropriate exercise can significantly reduce incidence and mortality of cardiovascular diseases and effectively improve prognosis of cardiovascular patients.Excercise has been regarded as effective in prevention and adjuvant treatment of cardiovascular diseases.Exercise has been shown to reduce inflammation,improve vascular endothelial function,regulate energy metabolism,and protect against myocardial damage.Nonetheless,the mechanisms mediating exercise-induced benefits for cardiovascular diseases are complex and many still remain to be elucidated.This review focuses on currently understood mechanisms related to exercise induced cardioprotection,with an emphasis on the important roles that insulin sensitization,endothelial cells,myocardial mitochondrial adaptations,and miRNAs play in producing the protected phenotype.
作者
王天册
李瑶
朱丽雯
张正斌
张冰
冯攀
孙阳
易蔚
WANG Tian-ce;LI Yao;ZHU Li-wen;ZHANG Zheng-bin;ZHANG Bing;FENG Pan;SUN Yang;YI Wei(Fourth Brigade,School of Basic Medicine Sciences,Xijing Hospital,Xi'an 710032;Second Clinical College,Shaanxi University of Chinese Medicine,Xianyang 712046,Shaanxi,China;Department of Geriatrics,Xijing Hospital,Xi'an 710032,Xi'an 710032,Shaanxi,China;Department of Cardiovascular Surgery,Xijing Hospital,Air force Medical University,Xi'an 710032,Shaanxi,China)
出处
《心脏杂志》
CAS
2019年第3期361-365,共5页
Chinese Heart Journal
基金
国家自然科学基金项目资助(81470477,81770345,81870266)
关键词
运动训练
心血管疾病
心血管保护
exercise training
cardiovascular disease
cardioprotection
