摘要
目的 探讨立体定向放射治疗非小细胞肺癌的疗效及对患者肺功能的影响。方法 选择非小细胞肺癌患者118例,根据治疗方案分为对照组(n=59例)和观察组(n=59例)。对照组采用常规分割放射技术治疗,观察组采用立体定向放射治疗,2组均连续治疗2个月,治疗完毕后对患者效果进行评估。参考美国RECIST1.1肿瘤客观疗效评价标准对2组疗效进行评估;采用platinumEliteDL型肺功能测定仪测定2组治疗前、治疗后3个月第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及二者比值(FEV1/FVC)水平。2组治疗完毕后对患者进行3年随访,记录并统计患者1年、2年及3年生存率,比较2组生存率及对患者肺功能的影响。结果 观察组采用立体定向放射治疗2个月后有效率为66.10%,高于对照组50.85%。观察组与对照组治疗前、治疗后2个月FEV1/FVC水平比较,差异无统计学意义(P>0.05);观察组与对照组治疗后2个月FEV1和FVC水平,均高于治疗前(P<0.05);观察组治疗后2个月FEV1和FVC水平,均高于对照组(P<0.05)。观察组采用立体定向放射治疗后1年、2年及3年生存率,均高于对照组(P<0.05)。结论 将立体定向放射用于非小细胞肺癌治疗有助于提高近期疗效,改善患者肺功能水平,提高患者生存率,值得推广应用。
Objective To investigate the effect of stereotactic radiotherapy on non-small cell lung cancer and its effect on lung function. Methods 118 patients with non-small cell lung cancer were selected and divided into the control group ( n =59 cases) and the observation group ( n =59 cases) according to the treatment plan.The control group was treated with conventional segmentation radiotherapy,the observation group was treated with stereotactic radiotherapy,and the 2 groups were treated continuously for 2 months.The effect of the patients was evaluated after the treatment.The efficacy of the 2 groups was evaluated with reference to the US RECIST 1.1 objective evaluation criteria for tumors;the forced expiratory volume (FEV1) and forced vital capacity (FVC) were measured in the 2 groups before and after treatment for 3 months using the platinumElite DL pulmonary function tester.And the ratio of the 2(FEV1/FVC) levels.After 2 years of treatment,the patients were followed up for 3 years.The 1-,2-,and 3-year survival rates of the patients were recorded and counted.The survival rate of the 2 groups and the effects on lung function were compared. Results After treatment with stereotactic radiotherapy for 2 months,the response rate was 66.10% in the observation group,which was higher than that of the control group (50.85%).There was no significant difference in the level of FEV1/FVC between the observation group and the control group before treatment and 2 months after treatment ( P >0.05).The levels of FEV1 and FVC in the observation group and the control group were higher than those before treatment.( P <0.05);the levels of FEV1 and FVC in the observation group were higher than those of the control group 2 months after treatment ( P < 0.05 ).The 1-,2-,and 3-year survival rates of the observation group after stereotactic radiotherapy were higher than those of the control group ( P <0.05). Conclusion The use of stereotactic radiotherapy for non-small cell lung cancer can improve the short-term efficacy,improve the lung funct
作者
董妍
吴尚
杨建国
DONG Yan;WU Shang;YANG Jianguo(Xinyang Central Hospital,Xinyang,464000)
出处
《实用癌症杂志》
2019年第6期960-963,共4页
The Practical Journal of Cancer
关键词
立体定向放射
非小细胞肺癌
近期疗效
肺功能水平
生存率
Stereotactic radiation
Non-small cell lung cancer
Short-term efficacy
Pulmonary function level
Survival rate
