摘要
目的探讨胶体果胶铋胶囊联合自拟益气肠化方改善慢性萎缩性胃炎(CAG)伴肠上皮化生(IM)患者的效果。方法选取CAG伴IM患者80例,随机分为联合组与对照组,每组40例。对照组给予胶体果胶铋胶囊治疗,联合组给予胶体果胶铋胶囊联合自拟益气肠化方治疗。比较2组治疗后的临床疗效、中医症状积分、胃黏膜病理积分以及胃功能指标[胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)]。结果联合组总有效率显著高于对照组(P<0.05)。治疗后,2组患者中医症状积分均较治疗前显著降低,且联合组显著低于对照组(P<0.05)。治疗后,2组腺体萎缩、肠上皮化生积分均较治疗前显著下降(P<0.05),且联合组显著低于对照组(P<0.05)。治疗后,2组患者PGⅠ水平较治疗前显著升高(P<0.05),PGⅡ水平显著下降(P<0.05),且联合组PGI水平显著高于对照组(P<0.05),PGⅡ水平显著低于对照组(P<0.05)。结论胶体果胶铋胶囊联合自拟益气肠化方治疗CAG伴IM患者的疗效确切,能显著改善患者的胃黏膜病理表现,有效调节胃蛋白酶原的水平。
Objective To investigate the influence of colloidal bismuth pectin capsules combined with selfmade Yiqi Changhua Regime on improvement of gastric function indexes in chronic atrophic gastritis (CAG) patients with intestinal metaplasia (IM). Methods Totally 80 patients with CAG and IM were randomly divided into combined group and control group, 40 cases in each group. The control group was treated with colloidal bismuth pectin capsules, while the combined group was treated with colloidal bismuth pectin capsules and self-made Yiqi Changhua Regime. The clinical efficacy, Scores of TCM symptoms, pathological score of gastric mucosa and gastric function indicators [pepsinogen Ⅰ(PG Ⅰ), pepsinogen Ⅱ(PG Ⅱ)] were compared between the two groups before and after treatment. Results The total effective rate of the combined group was significantly higher than that of the control group ( P <0.05). After treatment, the scores of TCM symptoms in both groups were significantly lower than those before treatment, and the combined group was significantly lower than the control group ( P <0.05). After treatment, the scores of gland atrophy and intestinal metaplasia in both groups were significantly lower than those before treatment ( P <0.05), and the combined group was significantly lower than the control group ( P <0.05). After treatment, the levels of PG I increased significantly and PG Ⅱdecreased significantly in both groups ( P <0.05), the level of PG Ⅰin the combined group was significantly higher than that in the control group ( P <0.05), and the level of PG Ⅱwas significantly lower than that in the control group ( P <0.05). Conclusion Bismuthcolloidal pectin capsule combined with self-made Yiqi Changhua Regime is effective in the treatment of CAG patients with IM, which can significantly improve the pathological manifestations of gastric mucosa and effectively regulate the level of pepsinogen.
作者
李阅桥
徐永居
LI Yueqiao;XU Yongju(Department of Pharmacy,Subei People′s Hospital,Yangzhou,Jiangsu,225001;Department of Digestion,Subei People′s Hospital,Yangzhou,Jiangsu,225001)
出处
《实用临床医药杂志》
CAS
2019年第12期75-78,82,共5页
Journal of Clinical Medicine in Practice
关键词
胶体果胶铋胶囊
自拟益气肠化方
慢性萎缩性胃炎
肠上皮化生
胃蛋白酶原
病理
colloidal bismuth pectin capsules
self-made Yiqi Changhua Regime
chronic atrophic gastritis
intestinal metaplasia
pepsinogen
pathology
