摘要
目的探讨结节性甲状腺肿(简称结甲)的临床病理特征及发病趋势的变化。方法对广西科技大学第二附属医院2012年1月—2017年12月间2569例结甲患者的性别、年龄、职业、病理类型等临床病理资料进行回顾及统计分析。结果女性2232例,平均发病年龄为45.82岁;男性337例,平均发病年龄为49.46岁。女性发病率占86.88%,女:男比例6.6:1。2569例结甲中有1367例伴继发改变,占53.21%。灶性淋巴细胞增生、继发改变、伴甲状腺功能亢进、桥本氏甲状腺炎分别为24.21%、19.81%、0.70%和0.43%。结甲伴乳头状增生占5.14%,结甲继发或并发癌变率2.92%,以乳头状癌发病率最高,占癌变比例86.67%;城市中年职业女性发病率最高,1594例,占女性患者71.42%。结论结甲病理类型复杂多样、继发改变多,其中乳头状癌与乳头状增生尤其应引起重视,应及早治疗或密切随访;发病率逐年有所增加,患病人群年龄呈年轻化,女性发病率高,除高碘摄入、食品污染、电离辐射等因素外,社会-心理-内分泌因素也可能是一项重要原因,应引起重视,积极干预。
Objective To investigate the clinical pathological features and incidence of nodular goiter(NG) between January 2012 and December 2017. Methods The clinical and pathological data of 2 569 patients with NG treated in our hospital in this period, including the gender, age, occupation and pathological type, was reviewed and statistically analyzed. Results There were 2 232 females, with an average age of 45.82 years, and 337 males, with an average age of 49.46 years. Female patients accounted for 86.88% of the total and the ratio of female patients to male ones was 6.6∶1. In the 2 569 cases of NG, 1 367 cases had secondary changes, accounting for 53.21%. Focal lymphocytic hyperplasia, secondary changes, hyperthyroidism and Hashimoto's thyroiditis accounted for 24.21%, 19.81%, 0.70% and 0.43% respectively. NG with papillary hyperplasia accounted for 5.14%. The rate of secondary or concurrent cancer of NG was 2.92%, with the highest incidence going to papillary carcinoma that accounted for 86.67% of the cases of cancer. The incidence of NG was the highest among middle-aged women in urban areas (1 594 cases), accounting for 71.42% of female cases. Conclusion The pathological types and secondary changes of nodular goiter are complex and varied, among which papillary carcinoma and papillary hyperplasia deserve more attention. Early treatment or close follow-up is essential. The incidence of the disease is increasing year by year, and there are more younger patients. Apart from high iodine intake, food pollution, ionizing radiation and other factors, social - psychological - endocrine factors may be also an important cause, so active intervention is needed.
作者
任传伟
张安文
REN Chuanwei;ZHANG Anwen(Pathological Teaching and Research Office,Medical College,Guangxi University of Science and Technology, Liuzhou Guangxi 450006, China)
出处
《空军医学杂志》
2019年第3期222-224,共3页
Medical Journal of Air Force
基金
广西科技大学自然科学项目(20161315)
关键词
甲状腺
结节性甲状腺肿
甲状腺癌
临床病理
发展趋势
thyroid gland
nodular goiter
thyroid cancer
clinical pathology
development trend
