摘要
目的:探讨左西孟旦治疗右心衰竭伴肺高血压的疗效和安全性。方法:选取2017年1月至2018年6月西安交通大学医学院第一附属医院收治的右心衰竭伴肺高血压患者136例,根据随机数字表法分为观察组和对照组,每组68例。对照组患者采用常规治疗,观察组患者在对照组治疗的基础上加用左西孟旦注射液。观察两组患者治疗前后世界卫生组织心功能分级、博格呼吸困难评分、6分钟步行试验(6-MWT)距离、血压、心率、生化指标水平、动脉血气分析指标水平、超声心动图指标水平及用药安全性。结果:治疗后,观察组世界卫生组织心功能分级Ⅲ级患者所占比例为86.8%(59/68),明显高于对照组的72.1%(49/68);观察组患者的博格呼吸困难评分明显低于对照组,上述差异均有统计学意义(P<0.05)。治疗后,观察组患者6-MWD距离明显优于对照组,差异有统计学意义(P<0.05),而两组患者收缩压、舒张压及心率水平的差异均无统计学意义(P>0.05);观察组患者总胆红素、直接胆红素、血清肌酐、尿素氮及血清N末端脑钠肽前体水平明显低于对照组,差异均有统计学意义(P<0.05),而两组患者血红蛋白计数、白细胞计数、血小板计数、丙氨酸氨基转移酶及天门冬氨酸氨基转移酶水平的差异均无统计学意义(P>0.05);观察组患者血二氧化碳分压水平明显低于对照组,血氧分压与血氧饱和度水平明显高于对照组,差异均有统计学意义(P<0.05);观察组患者右心房横径、收缩末期偏心指数水平明显低于对照组,左心室舒张末期内径、左心室收缩末期内径及三尖瓣环位移水平明显高于对照组,差异均有统计学意义(P<0.05)。观察组1例、对照组2例世界卫生组织心功能分级Ⅳ级特发性肺动脉高压患者出院后死亡,其余肺高血压患者未因右心衰竭再入院。结论:左西孟旦能有效改善右心衰竭伴肺高血压患者的临床症状,且耐�
OBJECTIVE:To probe into the efficacy and safety of levosimendan in treatment of patients with right heart failure accompanied with pulmonary hypertension.METHODS:Totally 136 patients with right heart failure accompanied with pulmonary hypertension admitted into the First Affiliated Hospital of Xi’an Jiaotong University from Jan.2017 to Jun.2018 were extracted to be divided into the observation group and the control group via the random number table,with 68 cases in each group.The control group was treated with conventional therapy,while the observation group received levocsimendan injection on the basis of the control group.The World Health Organization cardiac function grading,Borg dyspnea score,6-minute walk test (6-MWT) distance,blood pressure,heart rate,biochemical index,arterial blood gas analysis index,echocardiographic index and medication safety of two groups were observed before and after treatment.RESULTS:After treatment,the proportion of grade Ⅲ in WHO cardiac function grading of observation group was 86.8%(59/68),which was significantly higher than that of the control group 72.1%(49/68);the Borg dyspnea score of observation group was significantly lower than that of the control group,with statistically significant differences ( P <0.05).After treatment,the 6-MWT distance of observation group was significantly better than that of the control group,with statistically significant differences ( P <0.05),while there was no statistical significance in difference of systolic pressure,diastolic pressure and heart rate between two groups ( P >0.05 );levels of total bilirubin,direct bilirubin,serum creatinine,urea nitrogen and serum N-terminal brain natriuretic peptide precursor of observation group were significantly lower than those of the control group,with statistically significant differences ( P <0.05),while there were no statistical significance in differences of hemoglobin count,white blood cell count,blood platelet count,alanine aminotransferase and aspartate aminotransferase levels between two gro
作者
任丽
梁秀利
梁萧
田刚
朱丹军
REN Li;LIANG Xiuli;LIANG Xiao;TIAN Gang;ZHU Danjun(Dept.of Pharmacy,the First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Xi’an 710061,China;Dept.of Cardiology,the First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Xi’an 710061,China)
出处
《中国医院用药评价与分析》
2019年第5期555-559,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
西安市科技计划项目[No.SF1611(5)]
关键词
左西孟旦
右心衰竭
肺高血压
疗效
安全性
Levosimendan
Right heart failure
Pulmonary hypertension
Efficacy
Safety
