摘要
目的:探讨参麦注射液致过敏性休克的临床特点和发生规律,为临床合理用药提供参考。方法:检索中国期刊全文数据库(CNKI)和维普数据库(VIP),收集自1996年–2018年国内报道的参麦注射液致过敏性休克的不良反应病例,对患者的基本情况、药物使用情况和ADR临床表现等进行统计分析。结果:共有46例患者,参麦注射液致过敏性休克多为速发型过敏性休克,发生在给药时间10min内的占80.4%,女性发病率大于男性。过敏性休克以呼吸系统、循环系统以及中枢神经系统症状多见,其中45例症状缓解后痊愈,1例死亡。结论:参麦注射液致过敏性休克发病迅速,影响因素多,建议临床应严格按照药品说明书的要求进行使用,对患者加强用药监护。
Objective: To investigate the clinical features and the occurrence regularity of anaphylactic shock induced by Shenmai injection in order to provide references for rational drug use. Methods: Published reports of anaphylactic shock induced by Shenmai injection were searched and collected by CNKI and VIP database from 1996 to 2018. Ages and genders of the patients, drug use and clinical manifestations of ADRs were analyzed. Results: A total of 46 patients were invovled in this study, among which female patients were more than male patients. Most of anaphylactic shock induced by Shenmai injection were immediate anaphylactic shock. 80.4% of anaphylactic shock induced by Shenmai injection occurred within 10 minutes after administration. The symptoms of respiratory system circulatory system, and central nervous system were more common in anaphylactic shock. About 45 cases were cured and 1 cases died. Conclusion: Anaphylactic shock induced by Shenmai injection had a rapid onset and many influencing factors. It should be used strictly in accordance with the instructions and drug monitoring should be strengthened.
作者
张明
杨洋
叶伟军
谢法红
辛海莉
ZHANG Ming;YANG Yang;YE Wei-jun;XIE Fa-hong;XIN Hai-li(Outpatient Pharmacy, PLA General Hospital, Beijing100853, China;Clinical Pharmaceutical Center, PLA General Hospital, Beijing 100853, China)
出处
《中国药物应用与监测》
CAS
2019年第3期165-167,共3页
Chinese Journal of Drug Application and Monitoring
基金
解放军总医院临床科研扶持基金(2013FC-CXYY-1008)
关键词
参麦注射液
过敏性休克
合理用药
Shenmai injection
Anaphylactic shock
Rational drug use
