摘要
目的:探讨明胶海绵微粒经导管动脉化疗栓塞(GSMs-TACE)治疗肝细胞癌(HCC)的效果及对患者的免疫调节作用。方法:选取我院收集的HCC患者97例,根据TACE方法分为研究组49例(采用GSMs-TACE方法治疗)和对照组48例(采用碘化油TACE方法治疗),对比两种方法的治疗效果及对患者免疫功能的影响。结果:研究组的缓解率89.80%、总有效率97.96%,对照组缓解率81.25%、总有效率95.83%,两组患者比较,差异不具有统计学意义(P>0.05);治疗后,两组患者的血清AFP水平较本组治疗前均显著的降低(P<0.05),研究组的KPS评分高于对照组(P<0.05);治疗后,研究组的IL-1、IL-6水平低于对照组(P<0.05),研究组的CD3^+、CD4^+、NK水平显著的高于对照组(P<0.05);两组患者治疗后的IL-1、IL-6、TNF-α、CD8^+水平较治疗前显著的降低(P<0.05),CD3^+、CD4^+、NK水平较治疗前显著的升高(P<0.05);研究组的肝区疼痛、消化道不良反应发生率显著的低于对照组(P<0.05)。结论:GSMs-TACE与碘化油TACE治疗HCC患者的效果均肯定,但免疫调节GSMs-TACE具有优势。
Objective:To explore the effect of GSMs-TACE in the treatment of HCC and its immunomodulatory effects on patients.Methods:97 cases of HCC patients collected by our hospital were selected,according to the TACE method,including 49 cases of study group(using GSMs-TACE treatment) and 48 cases of control group(treated with iodized oil TACE),and the effects of the two methods were compared and the immune function of the patients was compared.Results:The remission rate of the study group was 89.80%,the total effective rate was 97.96%,the remission rate of the control group was 81.25% and the total effective rate was 95.83%.The difference between the two groups was not statistically significant(P>0.05).After treatment,the serum AFP levels of the two groups were significantly lower than those before treatment(P<0.05),the KPS score of the study group was higher than that of the control group(P<0.05).After treatment,the levels of IL-1 and IL-6 in the study group were lower than those in the control group(P<0.05),the levels of CD3^+,CD4^+ and NK in the study group were significantly higher than those in the control group(P<0.05).The levels of IL-1,IL-6,TNF-α and CD8^+ in the two groups were significantly lower than those before treatment(P<0.05).The levels of CD3^+,CD4^+ and NK were significantly higher than those before treatment(P<0.05).The incidence of liver pain and gastrointestinal adverse reactions in the study group was significantly lower than that in the control group(P<0.05).Conclusion:GSMs-TACE and lipiodol TACE are effective in the treatment of HCC patients,but immunomodulatory GSMs-TACE has advantages.
作者
王彬
Wang Bin(Radiotherapy Department,Xuchang Central Hospital,Henan Xuchang 461000,China)
出处
《现代肿瘤医学》
CAS
2019年第14期2538-2541,共4页
Journal of Modern Oncology
关键词
明胶海绵微粒
经导管动脉化疗栓塞
肝细胞癌
免疫调节作用
gelatin sponge particles
transcatheter arterial chemoembolization
hepatocellular carcinoma
immunomodulatory effects
