摘要
[目的]综述不同来源芍药中有效成分含量差异的研究进展。[方法]通过总结近10年的相关文献,比较浙江、安徽、河北、山东等地芍药,酒制、炒制、硫磺熏蒸等炮制方法,不同季节和生长年限采收的芍药,以及芍药根的不同部位,从不同产地、炮制方法、采收时间等方面阐明芍药中有效成分的含量差异。[结果]不同产地的芍药中芍药苷和芍药内酯苷含量差异明显。磐安、亳州等地的芍药中芍药苷和芍药内酯苷的含量较高。河北产的野生芍药,其芍药苷含量明显高于其他产地,而芍药内酯苷的含量并不高。其他成分的含量在不同产地芍药中的分布各有不同。不同炮制方法会导致芍药中有效成分的含量和种类发生变化,短时间的煎煮可有效提高芍药苷和芍药内酯苷的含量,酒制和炒制会降低芍药苷的含量,硫磺熏蒸则会促使芍药苷转变成芍药苷的磺酸盐,其他成分的含量也有不同程度的减少。与夏季相比,芍药更适合在春秋季采收,且合适的采收时间是在第二次生长之后。根皮可对化学成分的转化和流失起到一定的保护作用。[结论]磐安、亳州等地的芍药中芍药苷和芍药内酯苷含量较高,炮制会使芍药中其他有效成分产生不同程度的减少或转化,合适的采收时间应当在第二次生长之后。对儿茶素、没食子酸等含量的研究相对较少,因此对这些成分的含量差异还有待进一步研究。
[Objective]To review the research progress on the content differences of the active compounds in Paeoniae Radix.[Methods]By summarizing the relevant literatures in recent 10 years,this paper compared the Paeoniae Radix from Zhejiang,Anhui,Hebei,Shandong and other places.And compared Paeoniae Radix with sulfur-fumigated,stir-baking with bran,wine fried and other different processing methods.Also compared the Paeoniae Radix which harvested in different seasons,growing years and different parts of the root.To clarify the content differences of active ingredients in Paeoniae Radix from different geographical areas,processing methods and collecting time,etc.[Results]The content of paeoniflorin and albiflorin in Paeoniae Radix from different geographical areas was significantly different,which was higher in Pan’an and Bozhou.The content of paeoniflorin in wild Paeoniae Radix from Hebei Province was significantly higher than that in other areas,but the content of albiflorin was not high.The content of other ingredients in Paeoniae Radix from different geographical areas was different.Different processing methods will lead to changes in the content and types of effective compounds in Paeoniae Radix.A short time of decoction can effectively improve the content of paeoniflorin and albiflorin.The content of paeoniflorin will decrease by stir-baking with bran and wine fried.Sulfur fumigation can promote the transformation of paeoniflorin into the sulfonate of paeoniflorin.And the content of other ingredients also decreases to varying degrees.Compared with summer,Paeoniae Radix is more suitable for spring and autumn harvest.The right time to harvest is after the second growth.The bark of rhizome can protect the conversion and loss of chemical compounds.[Conclusion]The content of paeoniflorin and albiflorin in Paeoniae Radix in Bozhou and Pan’an are higher than in other places,and processing can reduce or transform other effective compounds in Paeoniae Radix with different degrees.The appropriate time for harvesting should
作者
沈梦兰
严斌俊
秦路平
SHEN Menglan;YAN Binjun;QIN Luping(Colley of Pharmaceutical Sciencet Zhejiang Chinese Medical University,Hangzhou (310053),China)
出处
《浙江中医药大学学报》
CAS
2019年第6期622-630,共9页
Journal of Zhejiang Chinese Medical University
基金
浙江省基础公益研究计划项目(LGF19H280005)
国家自然科学基金(81703462)
浙江省博士后科研择优资助项目(zj20180154)~~
关键词
芍药
有效成分
含量差异
芍药苷
芍药内酯苷
产地
炮制
采收时间
Paeoniae Radix
effective compounds
content difference
paeoniflorin
albiflorin
geographical areas
processing
harvest time
