摘要
目的:系统评估应用无针注射器与胰岛素笔注射胰岛素的安全性。方法:按照纳入和排除标准,计算机检索无针注射器与胰岛素笔的自身对照研究文献。对所纳入文献进行质量评价及提取资料后,采用Rev Man 5. 3软件进行Meta分析。结果:根据纳入排除标准共纳入2篇符合标准的文献,共64例患者,无针注射969例次,胰岛素笔注射889例次。Meta分析的结果表明,用无针注射器注射胰岛素后疼痛发生率、发生红肿硬结事件、药物残留率远远小于胰岛素笔,差异具有统计学意义(P均<0.000 01),仅出血/瘀斑发生率与胰岛素笔组相似,差异无统计学意义(P>0.57)。结论:无针注射器注射胰岛素可以减少疼痛、红肿硬结的发生率,药物残留少。
Objective: In this paper, we systematically evaluated the safety of insulin injection with needle-free syringe and insulin pen. Methods: According to inclusion and exclusion criteria, the self-control literature of needle-free syringes and insulin pens was retrieved by computer. After evaluating the quality of the included literature and extracting the data, the meta-analysis was carried out by using Rev Man 5.3 software. Results: According to the inclusion exclusion criteria, two articles with a total of 64 patients, 969 cases needle-free injection and 889 cases with insulin pen injection were included. The results of the meta-analysis showed that the incidence of pain, swelling and sclerosis and drug residue after insulin injection with needle-free syringe were much lower than those of insulin pen, and the differences were statistically significant(all P<0.000 01). The incidence of hemorrhage/ecchymosis was similar to that of insulin pen group, but there was no significant difference(P=0.57). Conclusions: Injecting insulin with needle-free syringe can reduce the incidence of pain, swelling and sclerosis, and can also reduce drug residue.
作者
刘占峰
宋少卿
任耘
Liu Zhanfeng;Song Saoqing;Ren Yun(Gynecology Obstetrics Hospital of Hedong District in Tianjin,Tianjin 300012;Community Health Service center of Chang-zhou Road Street of Hedong District in Tianjin,Tianjin 300250;General Hospital of Tianjin Medical University,Tianjin 300052)
出处
《天津药学》
2019年第3期23-27,共5页
Tianjin Pharmacy
