摘要
目的:探讨机械通气联合大剂量氨溴索治疗对老年重症肺部感染患者的影响。方法:将2016年1月至2018年6月间收治的84例老年重症肺部感染患者采用简单随机抽样法分为观察组和对照组,每组各42例。对照组予以机械通气联合常规剂量氨溴索,观察组予以机械通气联合大剂量氨溴索。比较两组临床疗效、症状改善时间、机械通气时间,评估治疗前、治疗1周后血气分析指标[动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)、氧化指数(PaO2/FiO2)]、评估治疗前、治疗2周后炎性指标[降钙素原(PCT)、C反应蛋白(CRP)]。结果:①干预2周后,观察组治疗总有效率高于对照组(P<0.05);②观察组发热、咳嗽、气促、肺部湿啰音症状改善时间及机械通气时间均短于对照组(P<0.05);③治疗1周后,两组PaO2、SaO2、PaO2/FiO2均高于治疗前(P<0.05),观察组增幅大于对照组(P<0.05);④治疗2周后,两组PCT、CRP水平均低于治疗前(P<0.05),观察组降幅大于对照组(P<0.05)。结论:机械通气联合大剂量氨溴索治疗老年重症肺炎良好,有利于控制患者PCT、CRP水平。
Objective:To explore the effects of mechanical ventilation combined with high-dose ambroxol on elderly patients with severe pulmonary infection. Methods:84 cases of elderly patients with severe pulmonary infection who were admitted between January 2016 and June 2018 were divided into observation group and control group according to the simple random sampling, with 42 cases in each group. Control group was given mechanical ventilation combined with conventional-dose ambroxol, and observation group was given mechanical ventilation combined with high-dose ambroxol. The clinical efficacy, symptoms improvement times and mechanical ventilation time were compared between the two groups. The blood gas analysis indexes [arterial partial pressure of oxygen (PaO 2), arterial oxygen saturation (SaO 2), oxidation index (PaO 2/FiO 2)] were evaluated before treatment and after 1 w of treatment, and the inflammatory indexes [procalcitonin (PCT), C-reactive protein (CRP)] were evaluated before treatment and after 2 w of treatment. Results:After 2 w of intervention, the total effective rate of treatment in observation group was higher than that in control group (P<0.05). The symptoms improvement times of fever, cough, shortness of breath and lung wet rales and the mechanical ventilation time in observation group were shorter than those in control group (P<0.05). After 1 w of treatment, the PaO 2, SaO 2 and PaO 2/FiO 2 in the two groups were higher than those before treatment (P<0.05), and the increases in observation group were greater than those in control group (P<0.05). After 2 w of treatment, the levels of PCT and CRP in the two groups were lower than those before treatment (P<0.05), and the decreases in observation group were greater than those in control group (P<0.05). Conclusions:Mechanical ventilation combined with high-dose ambroxol has good effects in the treatment of elderly patients with severe pneumonia, and it is beneficial to control the levels of PCT and CRP.
作者
蔡荣
CAI Rong(Maanshan Seventeen Metallurgical Hospital, Anhui Maanshan 243000, China)
出处
《河北医学》
CAS
2019年第6期965-969,共5页
Hebei Medicine
基金
安徽省自然科学基金,(编号:2016042178)
关键词
重症肺部感染
老年
大剂量氨溴索
机械通气
Severe pulmonary infection
Elderly
High-dose ambroxol
Mechanical ventilation
