摘要
目的:探讨血清心血管活性肽salusins水平与原发性高血压分级的相关性。方法:选择原发性高血压患者145例,其中高血压1级(45例)、高血压2级(52例)和高血压3级(48例),另选择同期血压正常的健康体检者50例为健康对照组,检测各组患者血脂、血清salusin-α与血清salusin-β水平并进行统计学分析。结果:与健康对照组比较,高血压患者血清salusin-α显著降低,随着高血压(1,2,3)级别上升,salusin-α水平逐级显著降低[(2.40±0.18)ng/ml比(1.17±0.33)ng/ml比(0.82±0.04)ng/ml比(0.60±0.09)ng/ml,P均=0.001];血清salusin-β水平显著升高,随着高血压(1,2,3)级别逐级显著升高[(2.47±0.28)ng/ml比(3.90±0.26)ng/ml比(4.43±0.09)ng/ml比(4.74±0.10)ng/ml,P均=0.001];Spearman相关分析显示,原发性高血压分级与血清salusin-α水平呈显著负相关(r=-0.936,P=0.001),与血清salusin-β呈显著正相关(r=0.526,P=0.001)。结论:血清心血管活性肽salusin-α与salusin-β对于高血压的预测具有一定临床意义,可为高血压治疗提供新的思路。
Objective:To explore correlation between stage cardiovascular active peptide salusin levels and class of essential hypertension (EH). Methods:A total of 145 EH patients were selected, including 45 cases of hypertension stage 1, 52 cases of stage 2 and 48 cases of stage 3. Another 50 healthy normotensive subjects undergoing physical examination simultaneously were enrolled as healthy control group. Levels of blood lipids, serum salusin-α and salusin-β were measured and compared among above groups. Results:Compared with healthy control group, there was significant reduction in serum salusin-α level, along with EH stage (1,2,3)rose, there was significant reduction in serum salusin-α level [(2.40±0.18)ng/ml vs.(1.17±0.33)ng/ml vs.(0.82±0.04)ng/ml vs.(0.60±0.09)ng/ml, P =0.001 all]in EH patients;there was significant rise in serum salusin-β level, along with EH stage (1,2,3) rose, there was significant rise in serum salusin-β level [(2.47±0.28)ng/ml vs.(3.90±0.26)ng/ml vs.(4.43±0.09)ng/ml vs.(4.74±0.10)ng/ml, P =0.001 all]in EH patients. Spearman correlation analysis indicated that EH stage was significant inversely correlated with serum salusin-α level ( r =-0.936, P =0.001), and significant positively correlated with serum salusin-β level ( r =0.526, P =0.001). Conclusion:Serum salusin-α and salusin-β possess certain predictive significance for hypertension stage, which may provide new thinking for antihypertensive therapy.
作者
赵婉晴
高伟勤
王忠
ZHAO Wan-qing;GAO Wei-qin;WANG Zhong(Department of Cardiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, 154002, China)
出处
《心血管康复医学杂志》
CAS
2019年第3期263-265,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
黑龙江省卫生厅科研项目(2013246)~~
关键词
高血压
肽类
血管
Hypertension
Peptides
Blood vessels
