摘要
噬菌体是一种能够裂解并杀死细菌的病毒,目前其作为鉴定细菌工具、应用于细菌分型及研发新型抗菌生物制剂等已成为研究热点。在肌尾噬菌体科中的T4类噬菌体属是现代遗传学和分子生物学的主要模型系统,对T4类噬菌体进行深入研究更具重要意义。本文从T4类噬菌体的分类,形态特征,与宿主的作用模式,以及从其应用及生物学意义方面进行综述,以期对T4类噬菌体有更深入了解。
Bacteriophage,defined as a virus that can disrupt and kill bacteria,has become a research hotpot currently by applying into bacteria identification techniques,bacterial typing and also the research of the new type of antimicrobial-biological preparations.New phages are usually found in the special places full of bacterial communities,such as soil,aquatic habitats,animal intestines,etc.A specific bacteriophage family that recognized as Myoviridae has been studied thoroughly by many researchers.T4-like phage,usually characterized as long polyhedral head and retractable tail is one of the Myoviridae.T4-like phage has been utilized as the main modeling system in the field of modern genetics and molecular biology,leading a research significance by further lucubrating it.In this particular research,the classification and morphological characteristics of T4-like phage,the interaction mechanism with its hosts and its biological significance are summarized for the purpose of a better and deeper understanding of it.
作者
叶玲玲
钟佑宏
王鹏
宋志忠
YE Ling-ling;ZHONG You-hong;WANG Peng;SONG Zhi-zhong(Department of Epidemiolo- gy and Health Statistics,Schoolof Public Health,Dali University,Dali 671000,Yunnan,China:2. Yunan Provincial Key Laboratory for Zoonosis Control and Prevention,Yunnan Institute for Endemic Disease Control and Prevention;Yunan Provincial Key Laboratory for Zoonosis Control and Prevention,Yunnan Institute for Endemic Disease Control and Prevention;Yunnan Center for Disease Control and Prevention)
出处
《中国病原生物学杂志》
CSCD
北大核心
2019年第5期606-609,共4页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.31660043)
云南省中青年学术和技术带头人后备人才培养项目(No.2014HB037)
云南省医学学科带头人培养对象项目(No.D-201652)
关键词
T4类噬菌体
命名
与宿主相互作用
应用
综述
T4-like bacteriophage
denominate
interacting with the host
application
review
