摘要
目的:建立珍菊降压片的合格性测试模型,考察近红外光谱分析技术在珍菊降压片质量分析中的应用。方法:以208批珍菊降压片为分析对象,用光纤法测定近红外光谱,建立定性、定量模型。结果:定性分析模型能体现不同生产企业、不同批次产品间的差异;定量分析模型能预测芦丁、氢氯噻嗪含量,芦丁定量模型均方根误差(RMSEP)为93.87、R^2为2.65,氢氯噻嗪定量模型RMSEP为87.59、R^2为1.52,初步判定制剂质量的优劣。结论:近红外分析技术可用于珍菊降压片定性、定量分析。
Objective:To establish a test model for the eligibility of Zhenju Jiangya Tablets and to investigate the application of near-infrared spectroscopy in the quality analysis of Zhenju Jiangya Tablets. Methods:Total 208 batches of Zhenju Jiangya Tablets were used as the analysis object,and the near-infrared spectroscopy was determined by optical fiber method to establish a qualitative and quantitative model. Results:The qualitative analysis model can reflect the differences between different enterprises and different batches of products. The quantitative analysis model can predict the content of rutin and hydrochlorothiazide. The quantita-tive model RMSEP of rutin was 93.87,R^2 was 2.65,and the quantitative model RMSEP of hydrochlorothiazide was 87.59,R^2 was 1.52,the quality of the preparation was preliminarily determined. Conclusion:Near-infrared analysis technology can be used for qualitative and quantitative analysis of Zhenju Jiangya Tablets.
作者
臧远芳
郭东晓
林永强
ZANG Yuanfang;GUO Dongxiao;LIN Yongqiang(Shandong Institute of Food and Drug Control,Jinan 250101,China)
出处
《山东中医药大学学报》
2019年第3期308-312,共5页
Journal of Shandong University of Traditional Chinese Medicine
关键词
近红外光谱
珍菊降压片
质量检测
芦丁含量
氢氯噻嗪含量
定性分析
定量分析
near infrared spectroscopy
Zhenju Jiangya Tablets
quality inspection
rutin content
hydrochlorothiazide content
qualitative analysis
quantitative analysis
