摘要
随着人们生活水平的提高,肥胖已成为一种普遍的健康问题。目前认为肥胖人群体内大多存在慢性低度炎症。脂肪组织具有重要的分泌功能,可分泌多种具有生物活性的分子,即脂肪因子。脂肪因子通过内分泌或旁分泌途径参与调节体内新陈代谢及炎症反应等。脂肪因子根据其在炎症方面的作用分为促炎因子、抗炎因子和发挥其他调节作用的物质,脂肪因子之间互相影响,共同调节肥胖的发生。本文主要针对几种脂肪因子在肥胖相关的炎症反应和胰岛素抵抗等方面的作用做一综述,旨在探讨脂肪因子对肥胖发生发展的影响。
With the improvement of living standard, obesity has become a common healthy problem. Most obese people may have mild chronic inflammation. Adipokines are bioactive molecules secreted by adipose tissue involved in metabolism and inflammation through endocrine or paracrine manners. According to the role in inflammatory response, adipokines are classified into pro-inflammatory, anti-inflammatory and regulatory factors. Adipokines can regulate the pathogenesis of obesity. This paper reviewed the effects of several adipokines on obesity-induced inflammatory response and insulin resistance.
作者
张明萌
张斌
饶敏腊
刘玉婷
马琪华
刘肖雨
廖小欣
李晓毅
刘新光
孙雪荣
Zhang Mingmeng;Zhang Bin;Rao Minla;Liu Yuting;Ma Qihua;Liu Xiaoyu;Liao Xiaoxin;Li Xiaoyi;Liu Xinguang;Sun Xuerong(Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Aging Research, Guangdong Medical University, Gunagdong Province, Dongguan 523808, China;Department of Biochemistry and Molecular Biology, Guangdong Medical University,Guangdong Province, Dongguan 523808, China;School of Basic Medicine, Guangdong Medical University, Guangdong Province, Dongguan 523808, China;the Second Clinical School, Guangdong Medical University, Guangdong Province, Donggtuin 523808, China;School of Laboratory Medicine, Guangdong Medical University, Guangdong Province, Dongguan 523808, China;Working at Institute of Biochemistry and Molecular Biology at the same time)
出处
《中国医药》
2019年第6期952-956,共5页
China Medicine
基金
国家自然科学基金(81671399)
广东省自然科学基金(2017A030307034)
广东医科大学国家级大学生创新创业训练计划(201810571013、201810571014)
广东医科大学大学生创新实验项目(ZYDB003、ZYDC001、ZYDC005)
广东大学生科技创新培育专项资金(pdjhb0231)~~
关键词
肥胖
促炎因子
抗炎因子
Obesity
Pro-inflammatory factors
Anti-inflammatory factors
