摘要
目的系统评价丹红注射液联合阿托伐他汀治疗不稳定心绞痛的疗效及安全性。方法对中国生物医学文献数据库、中国期刊全文数据库、维普期刊数据库、万方期刊数据库、Cochrane图书馆、PubMed、美国国立医学图书馆数据库,截止至2018年7月的中英文文献进行检索,选择符合纳入标准的随机对照试验(RCT)。对纳入文献进行数据提取,质量评估和数据分析,并使用RevMan5.3版软件进行Meta分析。结果共纳入22个研究,1910例受试者。丹红注射液联合阿托伐他汀在总体疗效方面较对照组更佳(RR=1.21,95%CI=[1.16,1.26],P<0.00001);在心电图改善方面、心绞痛改善方面和C反应蛋白(CRP)改变比对照组更有效,但在血脂改变、安全性方面两组差异无统计学意义(P>0.05)。结论丹红注射液联合阿托伐他汀治疗不稳定心绞痛疗效较单用一种注射剂及常规治疗显著。
Objective:To evaluate the efficacy and safety of Danhong Injection combined with atorvastatin on unstable angina. Methods:Chinese and English literatures were retrieved from China Biomedical Literature Database,China Journal Full Text Database,Wipe Journal Database,Wanfang Journal Database,Cochrane Library,PubMed and National Library of Medicine until July 2018. Randomized controlled trials(RCTs) that met the inclusion criteria were selected. Data extraction,quality assessment and data analysis were carried out for the included literature,and meta-analysis was carried out with RevMan 5.3 software. Results:A total of 22 studies and 1 910 subjects were included. Danhong Injection combined with atorvastatin was better than the control group in overall efficacy(RR=.21,95%CI=[1.16,1.26],P < 0.00001). ECG improvement,angina pectoris improvement and CRP changes were more effective than the control group,but there was no statistical difference in lipid changes and safety. Conclusion:Danhong Injection combined with atorvastatin on unstable angina is more effective than single injection and routine treatment,with high safety.
作者
姚奇谷
张琳成
陈冰
金伟锋
韩进
何岚
张宇燕
Yao Qigu;Zhang Lincheng;Chen Bing(Zhejiang Chinese Medical University,Zhejiang,Hangzhou 310053,China)
出处
《中国中医急症》
2019年第6期969-973,共5页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金项目(81473587)
浙江省自然科学基金项目(LR16H270001,LY17H270013)
浙江省大学生科技创新活动计划(新苗人才计划)(2018R410039)
