摘要
目的 探讨麻醉诱导前给予风湿性心脏病快室率房颤患者右美托咪定对于血流动力学、脑电双频指数(BIS)的影响。方法 选取我院2016年1月至2018年5月拟实施非心脏手术的风湿性心脏病快室率房颤患者84例,采用随机数字表法分为观察组合对照组各42例,两组患者均实施全麻下非心脏手术,观察组于麻醉诱导前给予右美托咪定0.6μg/kg,对比两组患者的心率(HR)、平均动脉压(MAP)、动脉血氧饱和度(SaO2)、BIS的变化。结果T0时刻,两组患者的HR、MAP、SaO2差异无统计学意义(P>0.05);在T1、T3、T4时刻,观察组患者的HR值均低于对照组,观察组T2时刻的HR值高于对照组,差异有统计学意义(P<0.05)。在T2、T3、T4时刻,观察组患者的MAP、SaO2值均高于对照组,差异有统计学意义(P<0.05)。T0、T1时刻,两组患者的BIS指数差异无统计学意义(P>0.05),在T2、T3、T4时刻,观察组患者的BIS值均高于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率11.90%显著的低于对照组的35.71%,差异有统计学意义(P<0.05)。结论 风湿性心脏病快室率房颤患者麻醉诱导前给予右美托咪定有利于维持手术患者的血流动力学及BIS指数稳定,减少麻醉过程中的不良反应。
Objective To investigate the effects of dexmedetomidine on hemodynamics and bispectral index(BIS)in patients with atrial fibrillation before and after induction of anesthesia. Methods In our hospital(January 2016-May 2018)84 patients with fast ventricular fibrillation with rheumatic heart disease(COR CHD)with non cardiac surgery were divided into 42 cases in the observation group,and the two groups were performed under general anesthesia without cardiac surgery.The observation group gave right metomomidine 0.6g/kg before induction of anesthesia,and compared the heart rate,mean arterial pressure(MAP),arterial oxygen saturation(SaO 2 )and BIS of the two groups.Results At the time of T0,the differences of HR,MAP and SaO2 in the two groups were not statistically significant( P >0.05).At the time of T1,T3 and T4,the HR values of the patients in the observation group were lower than those of the control group( P <0.05),and the HR values of the observation group were higher than those of the control group( P <0.05);at the time of T0 and T1,the difference of BIS index between the two groups was not statistically significant( P >0.05);at the time of T2,T3 and T4,the BIS values of the patients in the observation group were higher than those of the control group( P <0.05),and the incidence of adverse reactions in the observation group was significantly lower than that of the control group(35.71%( P <0.05). Conclusion Right metoomidin before induction of anesthesia in patients with rheumatic heart rate rapid ventricular rate is beneficial to maintain hemodynamics and BIS index stability and reduce adverse reactions in the process of anesthesia.
作者
张常伟
宋杰
Zhang Changwei;Jie Song(Department of Anesthesiology in Nantong First People′s Hospital,Nantong,Jiangsu 226001,China)
出处
《四川医学》
CAS
2019年第5期491-494,共4页
Sichuan Medical Journal
关键词
风湿性心脏病
房颤
右美托咪定
血流动力学
脑电双频指数
rheumatic heart disease
atrial fibrillation
dexmedetomidine
hemodynamics
bispectral index
