摘要
目的探讨康艾注射液联合多西他赛+卡铂(DC)化疗方案对晚期卵巢癌患者的临床疗效及免疫功能的影响。方法选择晚期卵巢癌患者97例,依据随机数字表法随机分为治疗组49例和对照组48例。对照组患者采用DC化疗方案治疗,治疗组在对照组基础上结合康艾注射液治疗。两组均以21d为1个化疗周期,连续化疗3~5个周期。比较两组疾病控制率、生活质量改善情况,化疗前后T淋巴细胞亚群变化及毒副反应发生情况。结果治疗组疾病控制率(87.76%)高于对照组(68.75%),差异有统计学意义(χ^2=5.16,P<0.05)。治疗组化疗后卡氏功能状态评分(KPS)评分高于对照组(t=6.24,P<0.05)。治疗组化疗后CD3^+、CD4^+和CD4^+/CD8^+高于对照组(t分别=22.81、13.79、14.29,P均<0.05)。治疗组胃肠道反应、血小板减少、白细胞减少和脱发发生率均低于对照组(χ^2分别=7.65、6.61、6.28、7.74,P均<0.05)。结论康艾注射液联合DC化疗方案治疗晚期卵巢癌患者疾病控制明显,且可改善患者生活质量和细胞免疫功能。
Objective To investigate the effect of Kang'ai injection combined with DC regimen chemotherapy on clinical efficacy and immune function in patients with advanced ovarian cancer.Methods The 97 patients with advanced ovarian cancer were randomly divided into treatment group(49 cases)and control group(48 cases).Patients in the control group were treated with DC chemotherapy,while patients in the observation group were treated with Kang'ai injection on the basis of the DC chemotherapy.21 days is a chemotherapy cycle,and 3~5 cycles of continuous chemotherapy are performed.The disease control rate,improvement of life quality,changes of T lymphocyte subsets and the occurrence of toxic and side effects were compared between the two groups.Results The disease control rate of treatment group (87.76%)was significantly higher than that of control group(68.75%)(χ^2=5.16,P<0.05).The Karnofsky performance status(KPS)score,CD3+,CD4+,and CD4+/CD8+ after chemotherapy of the treatment group were significantly higher than those of the control group(t=6.24,22.81,13.79,14.29,P<0.05).The incidences of gastrointestinal reaction,thrombocytopenia, leukopenia and alopecia in the treatment group were significantly lower than those in the control group(χ^2=7.65, 6.61,6.28,7.74,P<0.05).Conclusion Kang'ai injection combined with DC chemotherapy regimen has obvious therapeutic effect and can improve the quality of life and cellular immune function of patients with advanced ovarian cancer.
作者
范炜
彭佳
沈华
徐萍
FAN Wei;PENG Jia;SHEN Hua(Department of Gynaecology,Guangfu Hospital of Zhejiang Jinhua,Jinhua 321000,China)
出处
《全科医学临床与教育》
2019年第6期532-534,共3页
Clinical Education of General Practice
关键词
康艾注射液
DC化疗方案
晚期卵巢癌
生活质量
T淋巴细胞亚群
Kang'ai injection
DC chemotherapy regimen
advanced ovarian cancer
quality of life
T lymphocytesubsets
