摘要
目的探讨孕期增重过多对孕妇肠道菌群及妊娠结局的影响。方法选取2016年10月至2017年7月中国人民解放军联勤保障部队第九六七医院行产前检查并住院分娩的孕妇及其新生儿配对,共69对,根据孕期体质量增长情况,分为孕期体质量增长正常组和孕期体质量增长过多组,收集孕妇孕晚期粪便样本,分析孕妇粪便菌群的变化;比较两组孕妇妊娠期并发症、空腹血糖水平、血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]、新生儿出生体质量和新生儿并发症等数据。结果 (1)与孕期增重正常组相比,增重过多组孕妇肠道内肠杆菌、酵母高于增重正常组,而双歧杆菌、乳杆菌、拟杆菌低于增重正常组(Ps<0.05);(2)增重过多组血清TC、TG和LDL-C水平明显增高,HDL-C水平降低(Ps<0.05);(3)增重过多组妊娠期并发症发生率增加(P<0.05);(4)增重过多组新生儿体质量明显增加,导致巨大儿发生率明显升高,高胆红素血症的发生率也增加(P<0.05)。结论孕期增重过多孕妇肠道内菌群出现异常改变,导致母亲及子代并发症发生率增加,尽早进行干预治疗可能为降低发病率提供契机。
Objective To explore the effects of excessive weight gain during pregnancy on the gut microbiota and pregnancy outcome. Methods Sixty-nine pairs of pregnant women and their newborns who underwent prenatal examination and delivered in the No. 967 Hospital from October 2016 to July 2017 were selected as the subjects who were divided into excessive group(n=42) or non-excessive group(n=27) based on the weight gain during pregnancy. Fecal samples of 37-41 weeks pregnant women were collected to analyze the composition of intestinal microflora. The pregnancy outcome, levels of fasting blood glucose(FBG), serum lipids [total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C)], infant birth weight and neonatal complications were compared between the two groups. Results(1) The numbers of Enterobacters and Yeasts in excessive group were significantly higher than those in non-excessive group, while those of Bifidobacteria, Lactobacilli and Bacteroides in excessive group were significantly lower than those in non-excessive group(Ps<0.05);(2) The levels of TC, TG and LDL-C were significantly higher, while that of HDL-C was significantly lower in excessive group(Ps<0.05);(3) The incidence rate of complications of pregnancy was significantly higher in excessive group(P<0.05);(4) The birth weight of newborns, incidence of macrosomia and incidence of neonatal hyperbilirubinemia in the excessive group were significantly higher than those in the non-excessive group respectively(P<0.05). Conclusion The changes of intestinal flora in pregnant women with excessive weight gain during pregnancy lead to increased incidence of complications in mother and offspring. Interventions should be given as soon as possible.
作者
金玉
齐宸
管滔
郭艳杰
关怀
刘晓峰
JIN Yu;QI Chen;GUAN Tao;GUO Yanjie;GUAN Huai;LIU Xiaofeng(Department of Obstetrics and Gynecology ,No. 967 Hospital of PLA ,Dalian,Liaoning 116021,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第5期509-511,518,共4页
Chinese Journal of Microecology
基金
辽宁省自然科学基金(20180550166)
辽宁省自然科学基金(20170540904)
辽宁省教育厅一般项目(L2015143)
大连市医学科学研究计划项目(1712051)
关键词
孕期增重
肠道菌群
妊娠结局
Weight gain during pregnancy
Gut microbiota
Pregnancy outcome
