摘要
前蛋白转化酶枯草溶菌素9(PCSK9)对血浆低密度脂蛋白胆固醇(LDL-C)的代谢具有调节作用,使PCSK9抑制剂成为心血管领域调脂治疗的热点和生物制剂的开发热点,但生物制剂不良反应大,价格昂贵。目前文献报道许多天然产物具有调节PCSK9的作用,综述天然产物对PCSK9的调节作用及其作用机制,以期为PCSK9的小分子抑制剂开发提供参考。
Proprotein convertase subtilisin/kexin type 9(PCSK9) is the highligh of lipid-lowering therapy due to its effect on LDL-C in the cardiovascular field. PCSK9 inhibitor has become the hot spot in biological preparations in these years, but the properties of adverse reaction, high price and injection-methods of biologicals limit its development. Currently, it was reported that many traditional Chinese medicine and natural products had the functions of regulating PCSK9. This paper summarized the regulation and mechanisms of traditional Chinese medicine monomers, active ingredients, compounds and natural products on PCSK9 so as to provide references for the development of small-molecule inhibitors of PCSK9.
作者
刘艳
罗培
吴剑波
LIU Yan;LUO Pei;WU Jian-bo(Faculty of Chinese Medicine,Macao University of Science and Technology,Macao,China;Drug and Functional Foods Discovery Research Center,Southwest Medical University,Luzhou 646000,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第9期2229-2234,共6页
Chinese Traditional and Herbal Drugs
基金
四川省科技厅重点项目(18ZDYF3541)
四川省教育厅重点项目(14ZA0145)
四川省卫生厅应用基础研究项目(17PJ567)
关键词
前蛋白转化酶枯草溶菌素9
天然产物
PCSK9抑制剂
调脂作用
作用机制
proprotein convertase subtilisin/kexin type 9
natural products
PCSK9 inhibitor
lipid regulating effect
action mechanism
