摘要
自身免疫性肝病(autoimmune liver disease, AILD)是一组由自身免疫介导的肝胆损伤,其包括自身免疫性肝炎,原发性胆汁性胆管炎和原发性硬化性胆管炎.多项研究表明基因易感性、分子模拟、异常的免疫调节网络对AILD的发生与发展具有促进作用,但其自身免疫环境异常的原因至今尚未明确.目前认为,自身免疫性疾病的发生主要由自身免疫耐受机制破坏所致.调节性T细胞(regulatory T cells, Treg)是外周免疫耐受的关键,故可能在AILD中发挥重要的作用.本文从Treg细胞角度阐述AILD的发病机制,并对Treg细胞在AILD治疗中的应用作一阐述.
Autoimmune liver disease(AILD) is a group of autoimmunemediated hepatobiliary injuries, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. It has been demonstrated that gene susceptibility, molecular mimicry, and abnormal immune regulation networks contribute to the occurrence and progression of AILD, while the mechanism of the related abnormal immune environment remains undetermined. It is currently believed that autoimmune diseases are mainly caused by the destruction of autoimmune tolerance mechanisms. Regulatory T cell(Treg), as a key factor to peripheral immune tolerance, may play a critical role in AILD. This article aims to elucidate the pathogenesis of AILD from the perspective of Treg cells and provide insight into the application of Treg cells in the therapy of AILD.
作者
孙孟宇
刘文天
Meng-Yu Sun;Wen-Tian Liu(Department of Gastroenterology,General Hospital,Tianjin Medical University,Tianjin 300052,China)
出处
《世界华人消化杂志》
CAS
2019年第11期665-670,共6页
World Chinese Journal of Digestology
基金
天津市科委慢性病防治科技重大专项,No.17ZXMFSY00210
天津市卫计委卫生行业重点攻关项目,No.15KG149~~
