摘要
癌症是严重危害人类身体健康的主要疾病之一,经传统治疗后仍可能出现复发和转移,其根本原因是肿瘤组织中存在肿瘤干细胞(CSCs)。CSCs具有高度增殖、自我更新、多向分化、高度致瘤和多重耐药性等特征,控制着肿瘤的发生发展、化疗耐受、复发和转移等过程。因此,清除CSCs是提高癌症治愈率的有效方法之一。纳米载体具有尺寸小、比表面积大、生物相容性好、可体内降解等多项优点,常被用于靶向递送和缓释药物,为克服传统化疗药物的毒副作用、避免手术机械损伤和杀灭CSCs提供了可能。本文将对CSCs和纳米载药系统的特点,以及近年来纳米载药系统在CSCs中的研究进展做一综述。
Cancer is one of the major diseases that seriously endanger human health.Recurrence and metastasis may still occur after traditional treatment.The basic reason is the presence of cancer stem cells(CSCs)in tumor tissues.CSCs have a high degree of proliferative ability,self-renewal,multi-directional differentiation,highly tumorigenicity and multi-drug resistance,which control the occurrence and development of tumors,chemotherapy tolerance,recurrence and metastasis.Therefore,clearing CSCs is one of effective ways to improve the curative rate of cancer.Nano-carriers have many advantages such as small size,large specific surface area,good biocompatibility and degradation in vivo.They are often used for targeted delivery and sustained release of drugs,which overcome the toxic side effects of traditional chemotherapeutic drugs,avoid surgical damage and kill CSCs.This paper will review the characteristics of CSCs and nano drug-loading systems as well as their research progress of nano drug-loading systems in CSCs in recent years.
作者
朱琳
张春霞
ZHU Lin;ZHANG Chunxia(Department of Pharmacy,Wuhan Wuchang Hospital,Wuhan 430063,China)
出处
《实用肿瘤学杂志》
CAS
2019年第3期276-279,共4页
Practical Oncology Journal
关键词
纳米载药系统
肿瘤干细胞
靶向治疗
Nano-drug delivery system
Cancer stem cell
Targeted therapy
