摘要
目的了解影响睾丸显微取精结局的相关因素。方法回顾性分析2017年7月—2018年4月间74例因非梗阻性无精子症在广东省计划生育科学技术研究所(广东省计划生育专科医院)行睾丸显微取精手术患者的临床资料,根据取精结局分为获得精子组(A组)与未获精子组(B组),比较两组间的激素水平、睾丸体积、术前睾丸病理结果、术前治疗状况、术中生精小管饱满度、生精小管血供以及间质组织等状况,分析影响睾丸显微取精结局的相关因素。结果A组33例,B组41例,获精率44.59%。其中A组的术前治疗状况、生精小管饱满程度、间质组织增生状况与B组比较差异有统计学意义(P<0.05),而在激素水平、睾丸体积、生精小管的血供状况等指标比较差异无统计学意义(P>0.05)。40例术前曾行睾丸穿刺活检未见精子的患者中有17例找到精子,23例未找到精子,找到精子者与未找到精子者间的睾丸病理结果与取精结局比较差异亦无统计学意义(P>0.05)。结论激素水平、睾丸体积、睾丸穿刺病理结果、生精小管的血供丰富与否等指标不影响睾丸显微取精结局,生精小管饱满、睾丸间质组织中度增生处容易获得精子,而间质组织轻度或重度增生者均不易获得精子。
Objective To investigate the related factors affecting the outcome of testicular microextraction. Methods The clinical data of 74 patients with non obstructive azoospermia undergoing testicular microsurgery in Family Planning Research Institute of Guangdong Province (Family Planning Hospital of Guangdong Province) from July 2017 to April 2018 were retrospectively analyzed. According to the spermatozoa outcome, they were divided into sperm group (group A) and non-sperm group (group B). The hormone levels, testicular volume, preoperative testicular pathological results, preoperative treatment, plumpness of spermatogenic tubule, blood supply of spermatogenic tubule and interstitial tissue were compared, and the related factors affecting the outcome of testicular microextraction were analyzed. Results In 74 cases of non-obstructive azoospermia, 33 cases got sperm, 41 cases did not get sperm, and the sperm acquisition rate was 44.59%. Among them, preoperative treatment, seminiferous tubule plumpness and interstitial tissue hyperplasia in group A were significantly different from those in group B (P<0.05). But there was no difference in hormone levels, testicular volume and blood supply status of seminiferous tubules (P>0.05). Of the 40 patients who had not found sperm before operation, 17 of the patients found sperm, 23 cases did not find sperm, and there was no difference between the results of testicular pathology and the outcome of sperm extraction between those who found the sperm and those who did not find the spermatozoon (P>0.05). Conclusion Hormone level, testicular volume, testicular biopsy results, and abundant blood supply of seminiferous tubules do not affect the outcome of testicular microextraction. Spermatozoa are filled with seminiferous tubules and interstitial tissue of middle testis is easy to get spermatozoa.
作者
刘晃
郑厚斌
周雨
刘晓华
李倩仪
伍嘉宝
罗璐璐
庄嘉明
马春杰
张欣宗
唐运革
Liu Huang;Zheng Houbin;Zhou Yu;Liu Xiaohua;Li Qianyi;Wu Jiabao;Luo Lulu;Zhuang Jiaming;Ma Chunjie;Zhang Xinzong;Tang Yunge(Family Planning Research Institute of Guangdong (Family Planning Hospital of Guangdong Province), Key Laboratory of Male Reproduction and Genetics of State Health Commission, Guangzhou 510600, China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2019年第4期317-321,共5页
Chinese Journal of Reproduction and Contraception
基金
广东省医学科研基金项目(B2018250).
关键词
显微取精
影响因素
非梗阻性无精子症
Microscopic refinement
Influencing factors
Non-obstructive azoospermia
