摘要
突触小体相关蛋白-25基因(Synaptosomal-associated protein 25kDa gene,SNAP-25 gene)编码的SNAP-25蛋白是可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体(soluble NSF accessory protein receptor,SNARE)复合物的重要组分,其是突触小泡胞吐作用的核心,在神经元的突触前膜参与介导囊泡的募集、对接、膜融合和再循环。SNAP-25蛋白水平失调不仅影响神经的发育,还可影响多巴胺、5-羟色胺、谷氨酸等神经递质释放,进而参与精神分裂症的发生和发展过程。
The SNAP-25 protein encoded by Synaptosomal-associated protein 25kDa gene (SNAP-25 gene) is a soluble N-ethylmaleimide sensitive factor attachment protein receptor (soluble) as an important component of the NSF accessory protein receptor (SNARE) complex,which is the core of synaptic vesicle exocytosis,is involved in the recruitment,docking,membrane fusion and recycling of vesicles in the presynaptic membrane of neurons.The SNAP-25 protein level imbalance not only affects the development of nerves,but also affects the release of neurotransmitters such as dopamine,serotonin and glutamate,and then participates in the occurrence and development of schizophrenia.
作者
熊素素
李金
韦雅雪
王莹
林举达
XIONG Su-su;LI Jin;WEI Ya-xue;WANG Ying;LIN Ju-da(Guangdong Medical University,Zhanjiang,Guangdong Province,524001 China;Department of Psychiatry,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong Province,524001 China)
出处
《系统医学》
2019年第8期195-198,共4页
Systems Medicine
