摘要
目的:探索儿童重症肺炎支原体肺炎伴肺不张治疗中支气管肺泡灌洗术(bronchoalveolar lavage,BAL)的不同治疗时机与胸片恢复的关系。方法:选取 2017 年 1 月至 2018 年 2 月期间于重庆医科大学附属儿童医院确诊的重症肺炎支原体肺炎伴肺不张的患儿作为研究对象,根据行支气管肺泡灌洗术时病程分为 A 组(≤10 d,55 例)、B 组(10~20 d,94 例)、C 组(≥21 d,66例)。分别于术后 1 周及术后 1 个月左右复查胸片,比较 3 组患儿肺不张吸收情况。结果:3 组患儿术后 1 周随访胸片恢复情况比较:Kruskal-Wallis H 检验:χ^2=39.542,P=0.000。说明 3 组患儿术后 1 周随访胸片恢复情况存在统计学意义。进一步进行组间两两比较,A 组与 B 组比较(PAB=0.026);A 组与 C 组比较(PAC=0.000);B 组与 C 组比较(PBC=0.000);说明 3 组患儿术后 1 周随访胸片吸收情况,A 组优于 C 组,B 组优于 C 组,A 组及 B 组无明显差别。 3 组患儿术后 1 月随访胸片恢复情况比较:Kruskal-Wallis H 检验:χ^2=58.717,P=0.000。说明 3 组患儿术后 1 月胸片恢复情况存在统计学意义。进一步进行组间两两比较显示:A 组与 B 组比较(PAB=0.01);A 组与 C 组比较(PAC=0.000);B 组与 C 组比较(PBC=0.000);组间两两比较均具有统计学意义,说明 3 组患儿术后 1 月随访胸片恢复情况均存在差异,吸收情况 A 组优于 B、C 组,B 组优于 C 组。结论:对于重症肺炎支原体肺炎伴肺不张的患儿,BAL 早期介入(10 d 以内)有助于减轻病情、促进影像学恢复,从而改善预后。
Objective:To investigate the association of treatment timing of bronchoalveolar lavage (BAL) with chest X-ray recovery in children with severe Mycoplasma pneumoniae pneumonia and atelectasis. Methods:A total of 215 children who were diagnosed with severe mycoplasma pneumonia and atelectasis in Children’s Hospital Affiliated to Chongqing Medical University from January 2017 to February 2018 were enrolled as subjects,and according to the course of disease at the time of BAL treatment,they were divided into group A(≤10 days,55 children),group B(10-20 days,94 children),and group C(≥ 21 days,66 children). Chest X-ray was performed at one week and one month after surgery,and the recovery from atelectasis was compared between groups. Results:There was a significant difference in the recovery of chest radiograph between the three groups at one week after surgery,based on the Kruskal-Wallis H test(χ^2 =39.542,P=0.000). Further comparison between two groups showed that group A had a significantly better recovery of chest radiograph than group C(P=0.000),and group B had a significantly better recovery of chest radiograph than group C(P=0.000),while there was no significant difference between group A and group B(P=0.026). At one month after surgery,there was a significant difference in the recovery of chest radiograph between the three groups,based on the Kruskal-Wallis H test(χ^2 =58.717,P=0.000). Further comparison between two groups showed that group A had a significantly better recovery of chest radiograph than groups B and C(P=0.01 and 0.000),and group B had a significantly better recovery than group C(P=0.000). Conclusion:In children with severe Mycoplasma pneumoniae pneumonia and atelectasis,early BAL intervention (within 10 days) can help to alleviate their conditions,promote imag- ing recovery,and improve prognosis.
作者
王崇杰
耿刚
李莹
应林燕
代继宏
Wang Chongjie;Geng Gang;Li Ying;Ying Linyan;Dai Jihong(Department of Respiratory,the Children’s Hospital of Chongqing Medical University,Ministry of Education Key laboratory of Child Development and Disorder,China international Science and Technology Cooperation Base of Child Development and Critical Disorder,Chongqing Key Laboratory of Pediatrics)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2019年第5期649-652,共4页
Journal of Chongqing Medical University
基金
重庆市卫生计生委医学科研面上资助项目(编号:2017MSXM042)
关键词
儿童
肺炎支原体肺炎
肺不张
支气管肺泡灌洗
胸片
child
Mycoplasma pneumoniae pneumonia
atelectasis
bronchoalveolar lavage
chest radiograph
