摘要
目的研究阿尔茨海默病(AD)患者全脑表观扩散系数(ADC)与神经功能损害、同型半胱氨酸(Hcy)代谢、氧自由基生成的相关性。方法选择2014年3月至2017年12月期间在首都医科大学宣武医院诊断为AD的患者作为AD组,体检的健康者作为对照组。磁共振扫描后计算全脑ADC,采用蒙特利尔认知功能评估量表(MoCA)评价神经功能损害程度,采集血清后测定Hcy代谢指标、氧自由基生成指标的含量。结果 AD组患者顶叶、额叶、颞叶、枕叶的ADC水平与对照组比较差异无统计学意义(P>0.05),海马的ADC值以及血清中Hcy、丙二醛(MDA)、一氧化氮(NO)的含量明显高于对照组,MoCA评分以及血清中叶酸(FA)、维生素B12(VitB12)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH)的含量明显低于对照组(P<0.05);AD患者海马ADC值与MoCA评分以及血清中FA、VitB12、SOD、GSH的含量呈负相关,与血清中Hcy、MDA、NO的含量呈正相关。结论 AD患者海马ADC值的升高与认知功能损伤、Hcy代谢紊乱、氧自由基生成过多有关。
Objective To study the correlation of whole brain apparent diffusion coefficient (ADC) with neurological impairment, homocysteine (Hcy) metabolism and oxygen free radical generation in patients with Alzheimer′s disease (AD). Methods The patients diagnosed as AD in Xuanwu Hospital of Capital Medical University from March 2014 to December 2017 were selected as AD group and healthy persons as control group. The ADC of whole brain was calculated after magnetic resonance scanning. The degree of neurological impairment was evaluated by Montreal Cognitive Function Assessment Scale (MoCA). The levels of Hcy metabolic index and oxygen free radical production were measured after collecting serum. Results ADC values of AD group in parietal lobe, frontal lobe, temporal lobe and occipital lobe were not significantly different from those of control group (P>0.05). The ADC value of hippocampus as well as serum Hcy, malondialdehyde (MDA) and nitric oxide (NO) contents were significantly higher than those of control group, while MoCA score as well as folic acid (FA), vitamin B12 (VitB12), superoxide dismutase (SOD) and glutathione peroxidase (GSH) contents in serum were significantly lower than those of control group (P<0.05);ADC value of hippocampus in AD patients was negatively correlated with MoCA score as well as serum FA, VitB12, SOD and GSH contents, and positively correlated with serum Hcy, MDA and NO contents. Conclusions The increased ADC value of hippocampus in AD patients was related to the cognitive function injury, Hcy metabolism disorder and excessive generation of oxygen free radicals.
作者
刘江红
乔立艳
王丽
翟怡
张丽春
高乐虹
Liu Jianghong;Qiao Liyan;Wang Li;Zhai Yi;Zhang Lichun;Gao Lehong(Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China;Department of Neurology, Yuquan Hospital, Beijing 100040, China;Department of Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China)
出处
《中国医师杂志》
CAS
2019年第5期665-667,共3页
Journal of Chinese Physician
基金
国家自然科学基金(81301208)~~
关键词
阿尔茨海默病
弥散张量成像
认知功能障碍
高半胱氨酸
活性氧
Alzheimer disease
Diffusion tensor imaging
Cognitive dysfunction
Homocysteine
Reactive oxygen species
