摘要
目的观察益气滋阴活血泄浊法治疗糖尿病肾病慢性肾衰竭的临床疗效。方法将60例糖尿病肾病慢性肾衰竭患者随机分为对照组与治疗组,每组30例。对照组采用西医常规治疗,治疗组在对照组治疗基础上采用益气滋阴活血泄浊法治疗,2组疗程均为28 d。观察2组治疗前后肾功能指标[血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血浆黏度、纤维蛋白原水平和主要中医症状评分变化情况,统计2组临床疗效。结果治疗后,治疗组SCr、BUN、UA、TC、TG、LDL-C、血浆黏度、纤维蛋白原水平和中医症状评分与治疗前比较均明显降低(P均<0.05),HDL-C水平与治疗前比较差异无统计学意义(P>0.05);对照组SCr、BUN、UA、TC、TG、HDL-C、LDL-C、血浆黏度、纤维蛋白原水平与治疗前比较差异均无统计学意义(P均>0.05),中医症状评分与治疗前比较明显降低(P<0.05);治疗组治疗后SCr、BUN、TC、TG、LDL-C、血浆黏度、纤维蛋白原水平和中医症状评分均明显低于对照组(P均<0.05),UA、HDL-C水平与对照组比较差异均无统计学意义(P均>0.05);治疗组总有效率明显高于对照组(P<0.05)。结论益气滋阴活血泄浊法治疗糖尿病肾病慢性肾衰竭能够明显改善肾功能、血液流变学异常、脂代谢紊乱及临床症状,提高临床疗效。
Objective It is to observe the clinical therapeutic effect of therapy with replenishing Qi and enriching Yin, activating blood and purging turbid on chronic renal failure with diabetic nephropathy. Methods 60 patients with chronic renal failure with diabetic nephropathy were randomly divided into control group and treatment group, 30 cases in each group. The control group was treated with conventional western medicine. The treatment group was treated with the drugs for replenishing Qi and enriching Yin, activating blood and purging turbidon the basis of the control group.Both the courses of treatments were 28 days. The changes of renal function indexes [serum creatinine (SCr), urea nitrogen (BUN), uric acid (UA)], blood lipid index [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], plasma viscosity, fibrinogen and major TCM symptom scores before and after treatment were observed, and the clinical efficacy of the two groups were statistically analyzed. Results After treatment, the levels of SCr, BUN, UA, TC, TG, LDL-C, plasma viscosity, fibrinogen and TCM symptom scores of the treatment group were significantly lower than those before treatment ( P <0.05), the difference in HDL-C level was not significant compared with that before treatment ( P >0.05). There was no statistical difference in SCr, BUN, UA, TC, TG, HDL-C, LDL-C, plasma viscosity and fibrinogen between that before and ater treatment in the control group ( P >0.05), but TCM symptom scores were significantly lower than that before treatment ( P <0.05). The levels of SCr, BUN, TC, TG, LDL-C, plasma viscosity, fibrinogen and TCM symptoms after treatment in the treatment group were significantly lower than the control group ( P <0.05), but there was no significant difference in the UA and HDL-C levels between the two groups ( P >0.05). The total effective rate of the treatment group was significantly higher than that of the control group ( P <0.05). Conclusion The drugs fo
作者
何振生
王兰玉
王丽丽
赵长松
HE Zhensheng;WANG Lanyu;WANG Lili;ZHAO Changsong(Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, Hebei,China)
出处
《现代中西医结合杂志》
CAS
2019年第17期1843-1846,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省中医药管理局科研计划项目(2015230)
关键词
益气滋阴
活血泄浊
糖尿病肾病
慢性肾衰竭
replenishing Qi and enriching Yin
activating blood and purging turbidon
diabetic nephropathy
chronic renal failure
