摘要
目的:分析注射用血栓通中三七从原料到成品全过程的元素迁移规律,以便更好地控制成品中元素杂质。方法:采用ICP-MS法全面分析三七药材、三七总皂苷(中间体)和注射用血栓通中21种元素的含量。结果:21种元素的标准曲线相关系数r均在0. 999以上,回收率在92. 71%～107. 07%之间,RSD均在5%以内。三七药材中铝、铁含量较高,铅、砷、汞、镉、铜符合中华人民共和国药典的相关规定,三七总皂苷(中间体)和注射用血栓通中多数元素均未检出或含量极低。结论:注射用血栓通的提取工艺可有效去除三七中大部分元素,重金属及有害元素也降到较低水平。
Objective: To analyze the migration of elements in Thrombus Scavenger Injection from material to product,and to control the elemental impurities in products. Methods: The quantities of 21 elements in Panax notoginseng,Panax noteginseng saponins and Thrombus Scavenger Injection were determined by ICP-MS. Results: The correlative coefficients of standard curves of 21 elements surpassed 0.999,with the average recoveries ranged from 92.71% to 107.07% and their RSDs within 5%.The quantities of Al and Fe in Panax notoginseng were higher,while Pb,As,Hg,Cd,Cu was less than the standards of Chinese Pharmacopoeia.Most elements in Panax noteginseng saponins and Thrombus Scavenger Injection were not detected or were extremely low. Conclusion: The quantities of the heavy metal and hazard elements and other elements in Panax notoginseng were greatly reduced by the extraction process of Thrombus Scavenger Injection.
作者
程益清
夏晶
曹帅
李丽敏
付泽晓
周如洁
刘冠萍
梁云飞
毛秀红
朱小凤
季申
Cheng Yiqing;Xia Jing;Cao Shuai;Li Limin;Fu Zexiao;Zhou Rujie;Liu Guanping;Liang Yunfei;Mao Xiuhong;Zhu Xiaofeng;Ji Shen(Shanghai Institute for Food and Drug Control,Shanghai 201203,China;Guangxi Wuzhou Pharmaceutical (Group)Co.,Ltd.,Wuzhou 543002,China)
出处
《世界中医药》
CAS
2019年第4期805-808,共4页
World Chinese Medicine
基金
国家中药标准化项目(ZYBZH-C-GX-09)
科技部重点研发专项(2017YFC1700800)
上海科委技术标准专项(18DZ2200900)
广西壮族自治区科学技术厅重大专项计划(2015AC05038)
关键词
ICP-MS法
三七
注射用血栓通
三七总皂苷
重金属及有害元素
微波消解法
元素迁移
无机元素
Inductively coupled plasma mass spectrometry
Panax notoginseng
Thrombus scavenger injection
Panax noteginseng saponins
Heavy metal and hazard elements
Microwave digestion
Migration of elements
Inorganic elements
