摘要
目的探讨宫颈上皮内瘤变(CIN)Ⅱ和Ⅲ级术后人乳头瘤病毒(HPV)转阴患者再次感染高危型人乳头瘤病毒(HRHPV)的危险因素。方法对医院2016年5月至2018年7月收治的260例CIN Ⅱ和Ⅲ级术后HPV转阴患者的资料进行回顾性分析,患者术后均定期复查。统计患者一般资料及再次HR-HPV感染的发生情况并分析其危险因素。结果本组患者术后共22例再次HR-HPV感染,平均随访时间(8.92±1.10)个月;发生组受教育年限、间接接触、非单一性伴侣、合并阴道炎、有入住酒店经历、术后未使用干扰素者构成比均高于未发生组(P<0.05),且上述因素均为术后再次HR-HPV感染的独立危险因素。结论 CIN Ⅱ和Ⅲ级术后HPV转阴患者仍存在再次HR-HPV感染风险,危险因素较多,故应加强防控,从各个方面控制再次HR-HPV感染的风险。
Objective To explore the risk factors of reinfection of high-risk human papillomavirus(HR-HPV) in patients with negative human papillomavirus(HPV) after cervical intraepithelial neoplasia(CIN) Ⅱ and Ⅲ operation.Methods A retrospective analysis study was made on 260 patients with negative HPV after CIN Ⅱ and Ⅲ operation in our hospital from May 2016 to July 2018. All patients were reviewed regularly after operation. The general information and HR-HPV reinfection of patients were counted, and the risk factors were analyzed. Results There were 22 cases reinfection of HR-HPV after operation in this group. The average follow-up time was(8.92 ±1.10) months. The proportions of patients with years of education, indirect contact non-single sexual partner, vaginitis, hotel stay, and no use of interferon in the occurrence group were higher than those in the non-occurrence group(P<0.05), and above factors were independent risk factors for HR-HPV infection after operation. Conclusion There is still a risk of HR-HPV reinfection in patients with negative HPV after CIN Ⅱ and Ⅲ operation. There are many risk factors, so prevention and control should be strengthened to control the risk of of HR-HPV reinfection in all aspects.
作者
张倩丽
ZHANG Qian-Li(Pucheng County Hospital, Weinan 715500, China)
出处
《临床医学研究与实践》
2019年第16期103-104,共2页
Clinical Research and Practice
关键词
宫颈上皮内瘤变
人乳头瘤病毒
危险因素
cervical intraepithelial neoplasia
human papillomavirus
risk factors
