摘要
目的探讨泮托拉唑、多潘立酮片和铝碳酸镁三联治疗慢性胃炎的临床效果。方法 2016年12月至2018年5月,选择本院收治的108例慢性胃炎患者为研究对象,按照随机抽签方法将其分为对照组和观察组,各54例。对照组给予多潘立酮片联合铝碳酸镁治疗,观察组给予泮托拉唑、多潘立酮片和铝碳酸镁三联治疗。对两组患者的幽门螺杆菌(Hp)根除率、临床症状消失时间、胃镜疗效及不良反应发生情况进行观察及评估。结果治疗后,观察组Hp根除率高于对照组,差异有统计学意义(P<0.05)。观察组烧灼-反酸、上腹部疼痛、恶心呕吐-食欲不振等临床症状消失时间短于对照组,差异有统计学意义(P<0.05)。观察组胃镜治疗总有效率显著高于对照组,即观察组胃黏膜炎症减轻或消除情况优于对照组(P<0.05)。两组不良反应总发生率无显著差异(P>0.05)。结论泮托拉唑、多潘立酮片和铝碳酸镁三联治疗慢性胃炎具有较高的临床价值,能够在加快患者临床症状消失时间的同时保证用药安全性,具有较高的Hp根除率,值得应用及推广。
Objective To investigate the clinical effect of pantoprazole, domperidone and hydrotalcite triple therapy in the treatment of chronic gastritis. Methods From December 2016 to May 2018, 108 patients with chronic gastritis admitted in our hospital were selected as the research objects. The patients were divided into control group and observation group according to the random lottery method, with 54 cases in each group. The control group was treated with domperidone combined with hydrotalcite, while the observation group was treated with pantoprazole, domperidone and hydrotalcite triple therapy. The eradication rate of Helicobacter pylori(Hp), vanishing time of clinical symptoms, gastroscopic effect and adverse reactions of the two groups were observed and evaluated. Results After treatment, the Hp eradication rate in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). The vanishing time of clinical symptoms as burning-acid reflux, upper abdominal pain, nausea and vomiting-loss of appetite in the observation group were shorter than those in the control group, and the differences were statistically significant(P <0.05). The total effective rate of treatment under gastroscopy in the observation group was significantly higher than that in the control group, that is, the observation group was better than the control group in alleviating or eliminating gastric mucosal inflammation(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Pantoprazole, domperidone and hydrotalcite triple therapy has high clinical value in the treatment of chronic gastritis. It can accelerate the vanishing time of clinical symptoms, ensure drug safety and has a high eradication rate of Hp, which is worthy of application and promotion.
作者
高红霞
GAO Hong-xia(Bo'ai Hospital of Yan'an City, Yan'an 716000, China)
出处
《临床医学研究与实践》
2019年第16期35-37,共3页
Clinical Research and Practice
