摘要
目的探究不同剂量甘露醇治疗脑出血的临床效果。方法选取2015年1月至2018年5月在我院治疗的脑出血患者50例,根据患者入院治疗单双号顺序将其分为试验组与对照组,每组25例。试验组采用小剂量甘露醇治疗,对照组采用常规剂量甘露醇治疗。观察两组患者治疗前、后脑血肿体积、美国国立卫生研究院卒中量表(NIHSS)评分、综合痉挛量表(CSS)评分、治疗效果及不良反应发生情况。结果治疗7d后,两组患者脑血肿体积、NIHSS评分均改善,且试验组优于对照组,差异具有统计学意义(P<0.05)。治疗7d后,两组CSS评分均低于治疗前,且试验组低于对照组,差异具有统计学意义(P<0.05)。试验组临床治疗总有效率为88.00%,高于对照组的64.00%,差异具有统计学意义(P<0.05)。试验组不良反应总发生率为8.00%,低于对照组的32.00%,差异具有统计学意义(P<0.05)。结论脑出血患者应用小剂量甘露醇不仅可以改善其综合痉挛症状,还可以减少临床用药的不良反应,提升临床治疗效果,值得临床推广应用。
Objective To explore the clinical effects of different doses of mannitol in the treatment of cerebral hemorrhage.Methods A total of 50 patients with cerebral hemorrhage treated in our hospital from January 2015 to May 2018 were selected and divided into experimental group and control group according to the odd and even number of admission treatment, with 25 cases in each group.The experimental group was treated with low dose of mannitol, while the control group was treated with routine dose of mannitol.The volume of cerebral hematoma, National Institute of Health stroke scale (NIHSS) scores, composite spasticity scale (CSS) scores before and after treatment, therapeutic effects and adverse reactions were observed in the two groups.Results After 7 days of treatment, the volume of cerebral hematoma and NIHSS scores in the two groups improved, and those in the experimental group were better than the control group(P<0.05).After 7 days of treatment, the CSS scores in the two groups were lower than those before treatment, and those in the experimental group were lower than the control group, and the differences were statistically significant (P<0.05).The total effective rate of clinical treatment in the experimental group was 88.00%, which was higher than 64.00% in the control group, and the difference was statistically significant (P<0.05).The total incidence of adverse reactions of the experimental group was 8.00%, which was lower than 32.00% in the control group, and the difference was statistically significant (P<0.05).Conclusion Low dose of mannitol applied to patients with cerebral hemorrhage can not only improve the symptoms of comprehensive spasm, but also reduce the incidence of adverse reactions of clinical medication, and improve the clinical therapeutic effect, which is worthy of clinical promotion and application.
作者
李英琴
薛莉娜
LI Ying-qin;XUE Li-na(the People's Hospital of Ganquan County,Yan'an 716100,China)
出处
《临床医学研究与实践》
2019年第15期23-25,共3页
Clinical Research and Practice
关键词
甘露醇
脑出血
脑血肿
mannitol
cerebral hemorrhage
cerebral hematoma
