摘要
目的了解钦州市吸毒人群人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)和梅毒(TP)的感染状况,探讨HIV感染的影响因素,为制定疾病防控策略提供科学依据。方法选取2014年4月～2016年7月在钦州市辖区内活动的吸毒人员作为研究对象,通过问卷调查收集相关信息,并采集5.0 mL静脉血进行HIV、HCV及梅毒抗体检测。结果 3 148例研究对象中,男女性别比为37.9:1;平均(32.66±7.59)岁;HIV、HCV和梅毒感染率分别为4.7%、59.5%和3.6%;女性HCV和梅毒感染率高于男性(P<0.05),采用注射方式吸毒者HIV和HCV感染率则明显高于非注射方式吸毒者(P<0.05);多因素Logistic回归分析结果显示,年龄≥41岁(OR=9.50, 95%CI:1.25～72.38)、离异或丧偶(OR=1.83, 95%CI:1.06～3.17)、曾经共用针具(OR=2.95, 95%CI:2.06～4.22)和感染HCV(OR=6.43, 95%CI:3.32～12.46)是吸毒人群感染HIV的危险因素;在婚(OR=0.64, 95%CI:0.42～0.97)和知晓艾滋病相关知识(OR=0.55 95%CI:0.34～0.87)是吸毒人群感染HIV的保护因素。结论钦州市吸毒人群HIV、HCV和梅毒的感染率较高,感染HIV的影响因素较多,应针对各个因素制定综合干预措施,控制相关疾病的传播蔓延。
Objectives To investigate the infections of human immunodeficiency virus (HIV), hepatitis C Virus (HCV) and syphilis (TP), and to identify and explore the influencing factors of HIV infection among drug users in Qinzhou, in order to provide a scientific basis for formulating disease prevention and control strategies. Methods A questionnaire survey was conducted among drug users in Qinzhou in 2014- 2016, and venous blood samples collected for the serological detection of HIV, HCV and syphilis antigens and antibodies. Results A total of 3,148 drug users were monitored in 2014- 2016. The participants were mostly young men, with an average age of (32.66 ±7.59) years. The results of the survey indicated that the rate of drug injection and needles sharing increased year by year. It also revealed that the use of condoms in commercial sex declined. The positive rates of HIV, HCV and syphilis were 4.7 %, 59.5 % and 3.6%, respectively. The results of the Multivariate Logistic regression analysis showed that factors that the risk factors of HIV infection were as following, including participants over 40 years (OR =9.50, 95 % CI:1.25 ~72.38), divorced or widowed (OR=1.83, 95 % CI: 1.06~3.17), needle sharing (OR=2.95, 95 % CI: 2.06~4.22), and HCV infection (OR =6.43, 95% CI: 3.32 ~12.46). Married participants (OR =0.64, 95 %CI: 0.42 ~0.97), AIDS related knowledge and awareness (OR=0.55, 95 %CI: 0.34~0.87) was found to reduce the risk of HIV infection among drug users. Conclusions The infection rate of HIV, HCV and syphilis is high among drug users in Qinzhou, and high- risk lifestyles still exist. Therefore, the need to Strengthen public education and behavioral interventions are the key points of a successful prevention and control.
作者
林兆森
植建
陈慧莹
蒋家晓
陈裕鸿
梁冰玉
LIN Zhaosen;ZHI Jian;CHEN Huiying;JIANG Jiaxiao;CHEN Yuhong;LIANG Bingyu(Qinzhou Center for Disease Prevention and Control,Qinzhou,Guangxi 535099,China)
出处
《河南预防医学杂志》
2019年第6期401-404,417,共5页
Henan Journal of Preventive Medicine
基金
广西自然科学基金面上项目(2017JJA180904)
广西艾滋病防治研究重点实验室开放性课题(gklapt201704)
关键词
吸毒人群
HIV
梅毒
影响因素
Drug users
Drug addicts
HIV
HCV
Syphilis
Influencing factors
