摘要
目的探讨艾滋病病毒(HIV)感染者和艾滋病患者合并宫颈癌与癌前病变的相关影响因素。方法收集HIV感染、HIV合并宫颈癌与癌前病变患者208例,其中单纯HIV感染患者有102例,纳入对照组;另105例HIV合并宫颈癌与癌前病变患者纳入观察组。对所有患者进行宫颈癌与癌前病变检查、HPV检查。结果观察组患者中高危型HPV阳性率、HPV多重感染率、HPV阳性率显著高于对照组(P <0. 05)。HPV病毒承载量0～0. 99组宫颈炎发病率显著高于其他3组(P <0. 05); 100. 00～组CINⅢ发生率高于其他; 4组患者CINⅠ、CINⅡ发生率差异无统计学意义(P>0. 05)。艾滋病患者合并宫颈癌与癌前病变与孕次、多性伴侣、性病史、伴侣HIV抗体阳性有关(P <0. 05)。采用非条件多项式Logistic分析结果显示,HPV病毒载量与宫颈病变程度呈正相关(P <0. 000)。随着HPV病毒载量的升高,患者宫颈病变级别风险增大。结论艾滋病患者合并宫颈癌与癌前病变较单纯艾滋病病毒感染患者更易发生高危型HPV阳性、HPV多重感染情况,且HPV病毒载量与宫颈病变程度呈正相关。
Objective To investigate the influence factors of cervical cancer and precancerous lesions on patients with HIV/AIDS. Methods 208 patients with HIV,HIV complicated with cervical cancer,precancerous lesions were selected. 102 HIV patients were included into control group,and 105 HIV complicated with cervical cancer and precancerous lesions were included into observation group;All patients were examined for cervical cancer and precancerous lesions and HPV. Results The incidence of cervicitis in 0 ~ 0. 99 group was significantly higher than the other three groups( P < 0. 05);The incidence of CINⅢin the 10. 00 ~ group was significantly higher than that other three groups( P < 0. 05);No difference was found in the incidence of CINⅠ and CINⅡ between the four groups( P > 0. 05);AIDS patients with cervical cancer and precancerous lesions were related to pregnancy time,multiple sexual partner,venereal history,HIV-positive spouse( P < 0. 05);Unconditional polynomial logistic analysis showed that HPV viral load was positively correlated with cervical lesions( P < 0. 000). As the HPV viral load increased,the risk of cervical lesions increased. Conclusion Patients with AIDS combined with cervical cancer and precancerous lesions are more likely to have high-risk HPV positive and multiple HPV infection than those with simple HIV infection,and the HPV virus load is positively correlated with the degree of cervical lesions.
作者
吴菊意
校丽绒
胡泷
雷震涛
马赛
WU Juyi;XIAO Lirong;HU Long(Sixth People's Hospital of Zhengzhou,Zhengzhou,450015)
出处
《实用癌症杂志》
2019年第5期846-849,共4页
The Practical Journal of Cancer
