摘要
目的探讨黄连温胆汤辅以脑电仿生电刺激仪治疗脑卒中后痰热扰心型睡眠障碍的临床疗效。方法将符合纳入与排除标准的90例脑卒中后痰热扰心型睡眠障碍患者随机分为中药组、脑电仿生电刺激组和联合组各30例,中药组予以黄连温胆汤口服,脑电仿生电刺激组将电极放置在患者双侧乳突穴进行脑电仿生电刺激治疗,联合组予以黄连温胆汤联合脑电仿生电刺激治疗,3组均治疗30 d。观察3组治疗前后中医证候积分、匹兹堡睡眠质量指数(PSQI)变化情况,统计3组中医证候疗效、睡眠障碍疗效和不良反应发生情况。结果 3组患者治疗30 d后中医证候各项积分和总分、PSQI积分和总分均较治疗前明显降低(P均<0.05);联合组中医证候中睡眠不安、胸闷脘痞、口苦痰多、头晕目眩、舌红、苔黄腻积分及总分和PSQI各单项积分及总分均明显低于脑电仿生电刺激组(P均<0.05),中医证候各项积分和总分与中药组比较差异均无统计学意义(P均>0.05),但PSQI中睡眠质量、睡眠障碍、日间功能障碍积分和总分均明显低于中药组(P均<0.05);中药组中医证候中睡眠不安、胸闷脘痞、口苦痰多、头晕目眩、舌红、苔黄腻积分及总分和PSQI中入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能障碍积分及总分均明显低于脑电仿生电刺激组(P均<0.05)。联合组中医证候总有效率和睡眠障碍总有效率均明显高于脑电仿生电刺激组(P均<0.05),但中药组和脑电仿生电刺激组、联合组比较差异均无统计学意义(P均>0.05)。3组均无明显不良反应发生。结论黄连温胆汤联合脑电仿生电刺激仪治疗卒中后痰热扰心型睡眠障碍疗效明显优于单纯黄连温胆汤治疗和单纯脑电仿生电刺激仪治疗,且无明显不良反应。
Objective It is to investigate the clinical efficacy of Huanglian Wendan Decoction combined with electroencephalogram biomimetic stimulator on post-stroke sleep disorder of pattern of phlegm-heat harassing the heart. Methods Ninety patients with sleep disorder of pattern of phlegm-heat harassing the heart who met the inclusion and exclusion criteria were randomly divided into the Chinese medicine group, the electroencephalogram biomimetic stimulation group (ECG group) and the combined group, 30 cases in each group. The Chinese medicine group was given Huanglian Wendan Decoction orally. The ECG group was treated with electroencephalogram biomimetic stimulator by placing the electrodes in the bilateral mastoid points of the patients. The combined group was treated with Huanglian Wendan Decoction combined with EEG biomimetic stimulation. All the three groups were treated for 30 days. The changes of TCM syndrome scores and Pittsburgh Sleep Quality Index (PSQI) before and after treatment were observed. The efficacy of TCM syndromes, sleep disorders and adverse reactions were assessed. Results After 30 days of treatment, the scores of every item and total scores of TCM syndrome, PSQI scores and total scores were significantly lower than those before treatment in the two groups( P <0.05), the scores of TCM syndromes like restless sleep, chest tightness, bitter taste and excessive sputum, dizziness, red tongue, yellow greasy and total score, scores of every item and total scores of PSQI were significantly lower in the combined group than those in the EEG group ( P <0.05). There was no significant difference in the scores of every item and total scores of TCM syndrome between the Chinese medicine group and combined group ( P >0.05), but the scores of sleep quality, sleep disturbance, daytime dysfunction score and total score in PSQI were significantly lower in the combined group than those in the traditional Chinese medicine group ( P <0.05). The scores of sleeplessness, chest tightness, bitterness, dizziness, redness, ye
作者
朱金妹
何俊
朱海颖
王欢
季盼盼
ZHU Jinmei;HE Jun;ZHU Haiying;WANG Huan;JI Panpan(De’an Hospital of Changzhou, Changzhou 213000, Jiangsu, China)
出处
《现代中西医结合杂志》
CAS
2019年第15期1606-1610,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
常州市科技局资助项目(CE20175033)
关键词
脑卒中
睡眠障碍
黄连温胆汤
痰热扰心型
脑电仿生电刺激仪
stroke
sleep disorder
Huanglian Wendan Decoction
pattern of phlegm-heat harassing the heart
EEG biomimetic stimulator
