摘要
目的:观察病程2年以内类风湿关节炎临床表现随病程的演变规律。方法:从河南风湿病医院类风湿关节炎数据库(HFRA数据库)收录的409例患者中,选取病程为2年以内的患者共140例,以病程半年划分为4组,分别为半年以内组(A组)、半年到<1年组(B组)、1年到<1年半组(C组)、1年半到<2年组(D组),两两进行组间比较,得出4组患者在关节表现及关节外表现方面的区别和联系。结果:①左近指受限,A组> B组;左近指疼痛、右腕受限、左腕受限、关节畸形,A组<B组。②左肘疼痛,C组> D组;右踝肿胀,C组<D组。③左肘疼痛、神倦懒动、患病后体质量减轻,A组<C组。④关节畸形、患病后体质量减轻,A组<D组。⑤劳累后加重、渴喜热饮,B组> C组;左肘疼痛、右趾指疼痛、颈椎疼痛、左踝受限、神倦懒动、动则汗出,B组<C组。⑥抑郁、渴不欲饮,D组<B组;左踝柔韧感、易感冒、痰多,D组> B组。结论:随着病程延长,关节表现逐渐加重,并由上肢逐渐发展到下肢,下肢关节的破坏多出现在1年以后,证候由虚过渡为虚、痰、湿均明显,时间间隔大概1年。
Objective: To investigate the evolution of clinical manifestations of rheumatoid arthritis with the course of disease within 2 years.Methods:Four hundred and nine patients with rheumatoid arthritis in the database of Henan Rheumatism Hospital(HFRA database),a total of 140 patients with a course of less than 2 years were selected,then divided into four groups according to the course of disease for half a year:group A(within half a year),group B(from half a year to less than a year),group C(from a year to less than a year and a half)and group D(from a year and a half to less than 2 years).Two groups of them were respectively compared and differences and connections in joint and extraarticular manifestations of the four groups were obtained. Results:① The left proximal finger was limited more in group A than in group B(group A > group B),and as for pain in the left proximal finger,limitation of the right wrist,limitation of the left wrist and joint deformity,group A was better than group B(group A < group B).② The left elbow was more painful in group C than group D (group C > group D),and the right ankle swelling was less severe in group C than in group D(group C < group D).③ Group A was better than Group C on the aspects of the left elbow pain,mental fatigue and laziness,and the reduction of body weight after the illness (group A < group C).④ Group A was better than group D in the joint deformity and the reduction of body weight after disease (Group A < Group D).⑤ Group B was worse than group C on the aspects of aggravation after fatigue and thirst for hot drink(Group B > Group C),while group B was better than group C in left elbow pain,right toe pain,cervical pain,left ankle limitation,fatigue and laziness,sweating while moving(Group B < Group C).⑥ Group D was better than group B in depression and thirst without desire to drink(group D < group B),while group D was better than group B on the aspects of left ankle flexibility,susceptibility to cold and more phlegm(group D > group B).Conclusion:With the p
作者
丁琳琳
娄玉钤
DING Lin-lin;LOU Yu-Qian
出处
《风湿病与关节炎》
2019年第5期9-11,16,共4页
Rheumatism and Arthritis
基金
河南省中医药科学研究专项课题(20182Y3012)
关键词
关节炎
类风湿
病程
临床表现
辨证
HFRA
数据库
临床研究
arthritis,rheumatoid
course of disease
clinical manifestation
syndrome differentiation
HFRA database
clinical research
