摘要
目的观察消化性溃疡合并上消化道出血应用泮托拉唑治疗的临床效果。方法选取2016年5月-2017年12月在我院诊治的80例消化性溃疡合并上消化道出血患者作为研究对象,按不同治疗方法的差异,将其分为两组,每组各40例。对照组患者采用奥美拉唑治疗,观察组采用泮托拉唑治疗,比较两组患者的疗效及不良反应。结果观察组患者的治疗总有效率为95.00%,比对照组的77.50%高,组间比较,差异具有统计学意义(P<0.05);观察组止血时间为(12.56±1.74)h,比对照组的(14.68±2.96)h短,空腹胃液p H值为(5.56±0.63),比对照组(4.57±0.86)高,组间比较,差异具有统计学意义(P<0.05);观察组患者的不良反应发生率为5.00%,比对照组低,组间比较,差异具有统计学意义(P<0.05)。结论消化性溃疡合并上消化道出血通过泮托拉唑治疗后,能有效止血,抑制胃酸分泌,且不良反应少,提高临床疗效。
Objective To observe the clinical effect of pantoprazole in the treatment of peptic ulcer combined with upper gastrointestinal bleeding. Methods 80 patients with peptic ulcer complicated with upper gastrointestinal bleeding who were treated in our hospital from May2016 to December 2017 were selected as the study subjects. According to the difference of different treatment methods, they were divided into two groups, 40 cases in each group. The control group was treated with omeprazole. The observation group was treated with pantoprazole. The efficacy and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 95.00%, higher than77.50% of the control group. There was a significant difference between the two groups(P < 0.05). The hemostasis time of the observation group was(12.56±1.74) h, shorter than that of the control group(14.68±2.96)h, and the fasting gastric juice pH value was(5.56±0.63), higher than that of the control group(4.57±0.86). The difference between the two groups was statistically significant(P < 0.05). The incidence of adverse reactions in the observation group was 5.00%, which was lower than that in the control group. There was a significant difference between the two groups(P < 0.05). Conclusion Peptic ulcer combined with upper gastrointestinal bleeding can effectively stop bleeding and inhibit gastric acid secretion after treatment with pantoprazole, and the adverse reactions are less, which improves the clinical efficacy.
作者
廖丹
LIAO Dan(Department of Internal Medicine, Wuhan Wudong Hospital, Wuhan Hubei 430084, China)
出处
《中国继续医学教育》
2019年第15期141-143,共3页
China Continuing Medical Education
关键词
消化性溃疡
上消化道出血
泮托拉唑
奥美拉唑
止血
不良反应
peptic ulcer
upper gastrointestinal bleeding
pantoprazole
omeprazole
hemostasis
adverse reactions
