摘要
膝骨性关节炎(KOA)是退行性、多发性、难以治愈的疾病。KOA动物疾病模型是研究KOA发病机制、治疗方法及起效机制的有效载体。目前,诱导KOA动物模型的方法多种多样,各有其特点和适用性,本文通过对KOA动物模型选择与制备方法的文献进行综述比较,结合笔者对KOA动物模型的研究实践,探讨实验性KOA动物模型的选择与制备,以期对研究KOA动物模型提供有效参考。
Knee osteoarthritis (KOA) is a degenerative and intractable disease with high morbidity. Animal models of KOA provide an effective tool for studying the disease pathogenesis, potential treatments and their mechanism of action. A variety of animal models currently exist for studies of KOA, each with its own characteristics and advantages. In addition to the author’ s own research on animal models of this disease, this article reviews the literature on method ologies for establishing animal models of KOA. This article explores the selection criteria and method of preparing experimental KOA animal models, in order to provide an effective reference for researchers who wish to apply these models to their own work.
作者
吴强
郑倩华
蒋一璐
任润媛
李瑛
WU Qiang;ZHENG Qianhua;JIANG Yilu;REN Runyuan;LI Ying(Acupuncture and Tuina College/3rd Affiliated Hospital, Chengdu University of TCM, Chengdu 610075, China;Basic Medical College, Chengdu University of TCM, Chengdu 610075;Graduate Department,Chengdu University of TCM, Chengdu 610075)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第5期125-130,共6页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金重大项目(81590951)
成都中医药大学校基金资助项目(ZRQN1796)
关键词
骨性关节炎
动物模型
实验研究
osteoarthritis
animal model
experimental study
