摘要
目的 探讨阿司匹林联合小剂量氯吡格雷对高龄脑梗死患者神经功能的影响。 方法 选取高龄脑梗死患者120例,根据治疗方案分为2组各60例。对照组采用阿司匹林(100mg)治疗,观察组采用阿司匹林(50mg)+小剂量氯吡格雷(25mg)治疗。治疗14d后,比较2组治疗前后的神经功能、日常生活能力、疗效和不良反应发生情况。 结果 治疗后,观察组患者的脑卒中量表(NIHSS)评分显著低于对照组,Barthel评定量表(BI)评分显著高于对照组(P<0.05)。观察组总有效率91.67%,显著高于对照组的73.33%(P<0.05)。2组不良反应发生率比较无显著差异(P>0.05)。 结论 阿司匹林联合小剂量氯吡格雷治疗高龄脑梗死患者疗效显著,可有效促进患者神经功能恢复,提高日常生活能力。
Objective To investigate the effect of aspirin combined with small dose clopidogrel on neurological function in elderly patients with cerebral infarction. Methods Totally 120 elderly patients with cerebral infarction were selected and divided into two groups according to therapeutic regimens. The control group was treated with aspirin (100 mg), while the observation group was treated with aspirin (50 mg) plus small dose clopidogrel (25 mg). After 14 days of treatment, the neurological function, daily living ability, efficacy and incidence of adverse reactions before and after treatment were compared between two groups. Results After treatment, the stroke scale (NIHSS) score of the observation group was significantly lower than that of the control group, and the score of Barthel rating scale (BI) was significantly higher than that of the control group ( P <0.05). The total effective rate of the observation group was 91.67%, which was significantly higher than 73.33% of the control group ( P <0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups ( P >0.05). Conclusion Aspirin combined with small dose clopidogrel is effective in the treatment of elderly patients with cerebral infarction, which can effectively promote the recovery of neurological function and improve daily living ability.
作者
崔政
胡雪婷
CUI Zheng;HU Xueting(The Second Ward in Department of Neurosurgery,Yulin First Hospital,Yulin,Shaanxi,719000;Intensive Care Unit,Yulin First Hospital,Yulin,Shaanxi,719000)
出处
《实用临床医药杂志》
CAS
2019年第10期25-28,共4页
Journal of Clinical Medicine in Practice
关键词
阿司匹林
氯吡格雷
高龄患者
脑梗死
神经功能
aspirin
clopidogrel
elderly patients
cerebral infarction
neurological function
