摘要
目的探讨应用低分子肝素对老年慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效及相关指标的影响。方法选取106例老年AECOPD患者,分为对照组52例和观察组54例。对照组采用常规治疗,观察组在对照组基础上采用低分子肝素治疗,维持治疗10d。观察两组患者临床疗效及二氧化碳分压(PaCO_2)、氧分压(Pa O_2)、一秒用力呼气容积/用力肺活量(FEV1/FVC)、第1秒用力呼气容积占预计值百分比(FEV1%pred)、血纤维蛋白原(Fbg)、高敏C反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)的变化。结果治疗后,观察组患者的总有效率高于对照组(P<0.05)。两组患者治疗前各指标差异均无统计学意义(P均>0.05)。两组患者治疗后Pa O_2、FEV1/FVC、FEV1%pred水平均高于治疗前,PaCO_2、Fbg、hs-CRP、TNF-α水平均低于治疗前(P均<0.01)。观察组患者治疗后PaO_2、FEV1/FVC和FEV1%pred水平高于对照组,PaCO_2、Fbg、hs-CRP、TNF-α水平均低于对照组(P均<0.01)。结论应用低分子肝素治疗老年AECOPD患者疗效较好,可有效改善患者血气分析和肺功能,改善血液高凝状态,降低炎症反应,且无不良反应发生。
Objective To explore the effect of low molecular weight heparin on clinical efficacy and related indicators of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 106 elderly patients with AECOPD were divided into control group(52 cases)and observation group(54 cases).The control group was treated with conventional therapy,and the observation group was treated with LMWH on the basis of the control group for 10 days.The clinical efficacy and changes of partial pressure of carbon dioxide(PaCO2),partial pressure of oxygen(PaO2),forced expiratory volume per second(FEV1/FVC),forced expiratory volume per second(FEV1%pred),fibrinogen(Fbg),high sensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)were observed.Results After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in each index between the two groups before treatment(P>0.05).After treatment,the levels of PaO2,FEV1/FVC and FEV1%PRED in both groups were higher than those before treatment,while the levels of PaCO2,Fbg,hs-CRP and TNF-αwere lower than those before treatment(all P<0.01).After treatment,the levels of PaO2,FEV1/FVC and FEV1%PRED in the observation group were higher than those in the control group,while the levels of PaCO2,Fbg,hs-CRP and TNF-αin the observation group were lower than those in the control group(all P<0.01).Conclusion Low molecular weight heparin is effective in the treatment of elderly patients with AECOPD.It can effectively improve blood gas analysis and lung function,improve blood hypercoagulability,reduce inflammation and no adverse reactions.
作者
张永华
姜浩
刘芳
ZHANG Yonghua;JIANG Hao;LIU Fang(Ningxia People's Hospital of Wuzhong City,Wuzhong 751100,China;Yinchuan Traditional Chinese Medicine Hospital,Yinchuan 750001,China)
出处
《宁夏医科大学学报》
2019年第3期293-296,共4页
Journal of Ningxia Medical University
关键词
低分子肝素
慢性阻塞性肺疾病急性加重期
临床疗效
low molecular weight heparin
acute exacerbation of chronic obstructive pulmonary disease
clinical efficacy
