摘要
目的探讨慢性肾脏病(CKD)患者血清甲状旁腺激素(PTH)水平与肾功能的关系。方法选取149例CKD患者,依据我国慢性肾功能衰竭分期方法分为慢性肾功能不全代偿期组、慢性肾功能不全失代偿期组、慢性肾功能衰竭组、尿毒症组,另选取25名体检健康者作为对照组,比较各组PTH水平和生化指标差异,并做相关性分析。结果CKD各组血清PTH、尿素氮(BUN)、肌酐(Cr)、胱抑素C(CysC)、磷(P)水平均高于对照组(P<0.05),且随CKD分期的增加而逐渐升高(P<0.05);而血清钙(Ca)水平各组间差异无统计学意义(P>0.05);Pearson相关分析显示PTH与BUN、Cr、CysC、P均呈正相关(r值分别为0.442、0.616、0.563、0.376,P<0.01),与Ca呈负相关(r=-0.332,P<0.01)。结论PTH能够在一定程度上反映CKD的进展,监测慢性肾功能衰竭患者血清PTH水平有助于了解疾病的进展和评估疾病的严重程度。
Objective To investigate the relationship between parathyroid hormone (PTH) level and renal function in patients with chronic kidney disease (CKD). Methods A total of 149 patients with CKD were enrolled. According to the staging method of chronic renal failure in China,the CKD patients were classified into 4 groups (chronic renal insufficiency decompensated stage,chronic renal insufficiency compensated stage,chronic renal failure and uremia groups). Totally,25 healthy subjects were enrolled as healthy control group. PTH levels and biochemical indexes were compared and analyzed,and correlation analysis was conducted. Results Serum PTH,blood urea nitrogen (BUN),creatinine(Cr),cystatin C(Cys C) and phosphorus(P) levels in CKD group were higher than those in healthy control group (P<0.05),and they were gradually increased with CKD stages (P<0.05). There was no statistical significance for serum calcium(Ca)(P>0.05). Pearson correlation analysis showed that PTH was positively correlated with BUN,Cr,Cys C and P(r=0.422,0.616,0563 and 0.376,P<0.01),and it was negatively correlated with Ca(r=-0.332,P<0.01). Conclusions PTH could reflect the progress of CKD to some extent. Monitoring serum PTH level of patients with chronic renal failure may be helpful to understand the disease progress and evaluate the disease severity.
作者
邢小平
唐吉斌
王传发
孙芸
李旭光
吴道伟
宋元明
XING Xiaoping;TANG Jibin;WANG Chuanfa;SUN Yun;LI Xuguang;WU Daowei;SONG Yuanming(Department of Clinical Laboratory,Tongling People's Hospital,Tongling 244000,Anhui,China)
出处
《检验医学》
CAS
2019年第5期405-407,共3页
Laboratory Medicine
