摘要
目的研究冠状动脉闭塞段注入替罗非班对急性心肌梗死合并糖尿病患者血流现象及心功能的影响。方法采用随机数字表法将延安大学咸阳医院收治的90例急性心肌梗死合并糖尿病患者分成观察组与对照组,每组各45例,观察组采用冠状动脉闭塞段注入替罗非班治疗,对照组采用冠状动脉口处注射替罗非班治疗。探讨实施不同治疗对血流现象及心功能的影响。结果观察组无复流发生率(8.89%)明显低于对照组(24.44%),差异有统计学意义(χ~2=3.920,P=0.048)。治疗后,观察组左室射血分数、心率、左室舒张末期内径指标参数明显优于对照组,差异有统计学意义(P<0.05)。结论将冠状动脉闭塞段注入替罗非班治疗应用于急性心肌梗死合并糖尿病患者时,不仅能提升患者心功能,还能减少无复流发生率,此方法值得应用与推广。
Objective To explore the influence of subcutaneous injection with Tirofiban of coronary occlusion segment in the blood flow and cardiac function for acute myocardial infarction (AMI) patients with diabetes mellitus (DM). Methods A total of 90 AMI patients with DM treated in Xianyang Hospital of Yan′an University were selected and randomly assigned into observation group ( n =45) and control group ( n =45).Patients in observation group were injected with Tirofiban in coronary occlusion segment,and patients in the control group were treated with coronary artery ostium.The blood flow and cardiac function were compared. Results The no-reflow rate in observation group (8.89%) was significantly lower than that in control group (24.44%,χ^2=3.920, P <0.05).After treatment,the index of left ventricular ejection fraction and heart rate in the observation group were higher than that in control group while the left ventricular end-diastolic diameter was lower,with significant differences ( P <0.05). Conclusion The subcutaneous injection with Tirofiban in the coronary occlusion segment can improve patients′ cardiac function and reduce the no-reflow rate.It is worthy of clinical application and promotion.
作者
冯韩章
王淑珍
陈青
Feng Hanzhang;WANG Shuzhen;CHEN Qing(Cardiology Department Ⅲ,Xianyang Hospital of Yan′an University,Xianyang,Shaanxi 712000,China;Department of Cardiology,the Third People′s Hospital of Chengdu,Chengdu,Sichuan 610000,China)
出处
《检验医学与临床》
CAS
2019年第10期1370-1372,共3页
Laboratory Medicine and Clinic
关键词
急性心肌梗死
冠状动脉闭塞段
糖尿病
替罗非班
血流
acute myocardial infarction
coronary occlusion segment
diabetes mellitus
Tirofiban
blood flow
