摘要
干粉包衣技术根据促进包衣粉末黏附力的不同因素.主要分为3种类型:固体或液态辅助干粉包衣、热黏合干粉包衣和静电干粉包衣。干粉包衣工艺能避免使用大量有机溶剂或水,干燥时间较薄膜包衣技术大大缩短,通过选择不同的包衣材料还可制得具有掩味、缓释、肠溶等功能的片剂或微丸等固体制剂。本文主要综述了干粉包衣技术的分类、主要影响因素及目前在药剂学领域的应用进展。
Dry powder coating technique can be classified into solid-or liquid-assisted coating, thermal adhesion coating and electrostatic dry coating processes according to different factors promoting adhesive force of coating powders.Dry powder coating technique avoids using large amount of organic solvents or water, and significantly shortens drying time compared with thin film coating technique. Therefore, it has prominent advantages such as efficiency, safety and environmentally friendly features. By selecting coating materials with different functions, solid oral dosage forms such as tablets, pellets and capsules can achieve sustained-, prolonged-, or enteric-release and taste masking. The classification,main influence factors, and applications in pharmaceutics of dry powder coating techniques are reviewed in this paper.
作者
于盼盼
杨秋霞
侯琳
张焱
陆伟根
YU Panpan;YANG Qiuxia;HOU Lin;ZHANG Yan;LU Weigen(China State Institute of Pharmaceutical Industry, Shanghai 201203)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2019年第5期471-477,共7页
Chinese Journal of Pharmaceuticals
关键词
干粉包衣技术
辅助干粉包衣
热黏合干粉包衣:静电干粉包衣
影响因素
应用
dry powder coating technique
assisted coating
thermal adhesion coating
electrostatic dry coating
influence factor
application
