摘要
目的观察阿立哌唑治疗精神分裂症的疗效,并探讨其对患者体内糖类和脂类代谢的影响。方法选取西安市精神卫生中心精神科2017年4月至2018年4月间收治的86例精神分裂症患者作为研究对象,根据患者住院号排序后按随机数字重新排序分为观察组和对照组,每组43例。观察组患者给予阿立哌唑治疗,对照组患者给予奥氮平治疗,两组均治疗6周,比较两组患者治疗前后的空腹血糖(FPG)、餐后2 h血糖水平,以及高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯(TG)、总胆固醇(TC)等血脂水平,采用阳性与阴性症状量表(PANSS)评价治疗效果。结果观察组和对照组患者的临床治疗总有效率分别为86.05%和88.37%,差异无统计学意义(P>0.05);治疗前两组患者的FPG和餐后2 h血糖指标比较差异均无统计学意义(P>0.05);治疗后观察组患者的FPG和餐后2 h血糖分别为(5.68±0.50) mmol/L、(7.29±1.24) mmol/L,均明显低于对照组的(6.77±0.64) mmol/L、(8.26±1.39) mmol/L,差异均具有统计学意义(P<0.05);治疗前后两组患者的HDL、LDL、TC水平比较差异均无统计学意义(P>0.05),但治疗后对照组患者TG水平为(0.98±0.16) mmol/L,明显高于其治疗前的(0.74±0.13) mmol/L和观察组治疗后的(0.73±0.12) mmol/L,差异均具有统计学意义(P<0.05)。结论阿立哌唑治疗精神分裂症患者的疗效与奥氮平相当,但是对患者血糖和血脂影响水平明显小于奥氮平。
Objective To investigate the effect of aripiprazole on the metabolism of carbohydrates and lipids in schizophrenic patients. Methods Eighty-six schizophrenic patients admitted to Xi'an Mental Health Center from April 2017 to April 2018 were divided into study group (43 patients) and control group (43 patients) according to their hospitalization numbers to receive aripiprazole and olanzapine, respectively, both for 6 weeks. The levels of fasting blood glucose (FPG), postprandial 2 h blood glucose, high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), and other blood lipids were measured before and after treatment, and the therapeutic effect was evaluated by positive and negative symptom scale (PANSS). Results The total clinical effective rate of the two groups was 86.05% and 88.37%, respectively, with no significant difference between the two groups (P>0.05). Before treatment, there was no significant difference in fasting blood glucose and postprandial 2 h blood glucose between the two groups (P>0.05);after treatment, the FPG and postprandial 2 h blood glucose of the study group were (5.68±0.50) mmol/L,(7.29 ± 1.24) mmol/L, respectively, significantly lower than (6.77 ± 0.64) mmol/L,(8.26 ± 1.39) mmol/L in the control group (P<0.05). There was no significant difference in HDL, LDL, and TC between the two groups before and after treatment (P>0.05), but, the TG level in the control group after treatment was (0.98±0.16) mmol/L, which was significantly higher than (0.74±0.13) mmol/L before treatment and (0.73±0.12) mmol/L after treatment in the study group (P<0.05). Conclusion Aripipiprazole has the same effect as olanzapine in the treatment of schizophrenia, but its effect on blood glucose and lipid is less than olanzapine.
作者
胡江
李文
王莉莉
HU Jiang;LI Wen;WANG Li-li(Department of Psychiatry,Xi 'an Mental Health Center,Xi'an 710061,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第9期1114-1116,共3页
Hainan Medical Journal
关键词
精神分裂症
药物疗法
阿立哌唑
疗效
血糖
血脂
Schizophrenia
Drug therapy
Aripiprazole
Efficacy
Blood sugar
Blood lipids
