摘要
【目的】应用数据挖掘的方法,探讨明清时期医家治疗崩漏的组方用药规律。【方法】以明清时期37部女科典籍为检索源,将符合标准的方剂纳入,提取方剂组成信息,并采用Excel建立原始数据文件,进行频数分析;借助SPSS Statistic22.0、SPSS Modeler 14.1分别对高频药物进行聚类分析、关联分析。【结果】共得到治疗崩漏的方剂117首,包含中药119味,药物使用总频次为936。所用中药可归为17类,补虚药中的补血药、补气药用药频率较高,祛邪药中的清热药、止血药、活血化瘀药用药频率较高。单味高频药物有当归、甘草、川芎、熟地黄、白芍、白术、人参、黄芩等。聚类分析和关联分析的结果得到6个核心药物组合,分别为熟地黄—川芎、白术—黄芪、生地黄—黄芩、柴胡—山药、蒲黄—侧柏叶、茯苓—棕榈炭。【结论】明清医家治疗崩漏补虚时以补血、补气类别为主,祛邪时以清热、化瘀、止血为主,数据挖掘结果与传统理论相吻合,可为临床治疗崩漏遣方用药提供理论依据。
Objective To explore the medication rules of the practitioners’ prescriptions in Ming and Qing Dynasties for the treatment of metrorrhagia and metrostaxis with data mining methods. Methods A total of 37 monographs for women’s diseases written in Ming and Qing Dynasties were retrieved,and the prescriptions for the treatment of metrorrhagia and metrostaxis were included for the data extraction. The original data file was established with Excel,and frequency analysis was performed. SPSS Statistic 22.0 and SPSS Modeler 14.1 were adopted for the cluster analysis and association analysis. Results A total of 117 prescriptions involving 119 herbs for the treatment of metrorrhagia and metrostaxis were obtained,with the total medication frequency of herbs being 936. The 119 herbs can be classified into 17 categories,and a higher medication frequency was present in the herbs for nourishing blood and the herbs for replenishing Qi from the deficiency-tonifying categories,and in the herbs for clearing heat,herbs for stopping bleeding and herbs for activating blood and removing stasis from the pathogen-eliminating categories. Single herbs of Radix Angelicae Sinensis(Danggui), Radix Glycyrrhizae(Gancao),Rhizoma Chuanxiong(Chuanxiong),Radix Rehmanniae Preparata(Shudihuang),Radix Paeoniae Alba(Baishao), Rhizoma Atractylodis Macrocephalae(Baizhu), Radix Ginseng(Renshen), and RadixScutellariae(Huangqin)had higher medication frequency. After clustering analysis and correlation analysis, 6 core herbal combinations were obtained, and they were Shudihuang-Chuanxiong, Baizhu-Radix Astragali(Huangqi), Radix Rehmanniae(Shengdihuang)-Huangqin, Radix Bupleuri(Chaihu)-Rhizoma Dioscoreae(Shanyao),Pollen Typhae(Puhuang)-Cacumen Platycladi(Cebaiye),and Poria(Fuling)-Fibra Trachycarpi Carbonisatus(Zonglyutan). Conclusion The practitioners’ prescriptions in Ming and Qing Dynasties for the treatment of metrorrhagia and metrostaxis are characterized by tonifying deficiency mainly with the herbs for nourishing blood and the herbs for replenishi
作者
赵小萱
姜月蓬
曹雯雯
冯晓玲
ZHAO Xiao-Xuan;JIANG Yue-Peng;CAO Wen-Wen;FENG Xiao-Ling(Heilongjiang University of Chinese Medicine,Harbin 150040 Heilongjiang,China;The First AffiliatedHospital of Heilongjiang University of Chinese Medicine,Harbin 150040 Heilongjiang,China)
出处
《广州中医药大学学报》
CAS
2019年第6期919-924,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(编号:81574014
81373673)
关键词
明清时期
崩漏
补血
补气
清热
止血
活血化瘀
数据挖掘
Ming and Qing Dynasties
metrorrhagia and metrostaxis
nourishing blood
replenishing Qi
clearing heat
stopping bleeding
activating blood and removing stasis
data mining
