摘要
目的:评价柴胡加龙骨牡蛎汤对少阳型消渴病伴不寐患者的临床疗效。方法:受试对象80例用随机分成两组,包括对照组38例,治疗组42例。对照组在原降糖方案治疗的基础上予艾司唑仑片治疗,治疗组在原降糖方案治疗的基础上予柴胡龙骨牡蛎汤口服,治疗周期为15 d。观察两组血糖水平、PSQI评分及中医证候积分的变化。结果:组内比较:治疗后,两组患者血糖、PSQI评分、中医证候积分均有显著性差异(P<0.05),提示两组治疗均有临床疗效。组间比较:治疗前,两组患者的血糖水平、PSQI评分及中医证候积分无显著差异(P>0.05),具有可比性。治疗后,与对照组相比,治疗组的血糖水平、中医证候积分有显著性差异(P<0.05),提示治疗组在改善血糖水平及中医证候积分方面显著优于对照组;而在改善PSQI评分方面,治疗组与对照组无显著性差异(P>0.05),提示在改善睡眠质量方面,尚不能认为两组有不同疗效。两组临床疗效有显著性差异(P<0.05),表明在改善治疗组的临床疗效优于对照组。且治疗组的不良反应显著低于对照组(P<0.05)。结论:两组治疗方案均可降低血糖水平、中医证候积分、PSQI评分,但治疗组在改善中医症状及降低血糖方面疗效显著优于对照组,而在改善PSQI评分方面则尚不能认为两组疗效有差异;柴胡龙骨牡蛎汤在改善整体症状方面疗效显著优于艾司唑仑组。表明睡眠质量与血糖水平有一定的联系,且柴胡加龙骨牡蛎汤在降血糖的同时,还具有镇静助睡眠的作用,且不良反应少,值得临床进一步推广。
Objective:To explore the clinical curative effects of Chaihu Longgu Muli Decoction on the treatment of Shaoyang T2 DM with insomnia. Methods:The 80 trial patients randomized into the control group and the treatment group,with the control group 38 cases and the treament group 42 cases,for 15 days treatment,the control group was given basic treatment and Eszolam tablet,and the treament group was treated with Chaihu Longgu Muli Decoction which were treated on the basis of the basic treatment.Observed the changes of blood glucose levels,PSQI scores and TCM syndrome scores. Results:Intragroup comparison:there were significant differences in blood glucose,PSQI scores,and TCM syndrome scores between the two groups after treatment(P<0.05),suggested that there were clinical efficacy in both groups. Comparison between groups:before treatment,there was no significant difference in blood glucose level,PSQI score and TCM syndrome score between the two groups(P>0.05),which means it was comparable. After treatment,there were significant differences in blood glucose level and TCM syndrome score between the treatment group and the control group(P<0.05),suggested that the treatment group was significantly better than the control group in improving blood glucose level and TCM syndrome scores. In terms of improving PSQI score,there was no significant differences between the treatment group and the control group(P>0.05),suggested that the two groups could not be considered to have different efficacy in improving sleep quality. There was significant differences in clinical efficacy between the two groups(P<0.05),suggested that the two groups could be considered to have a difference in the overall clinical efficacy. And the adverse reactions in the treatment group were significantly lower than those in the control group(P<0.05). Conclusion:Both the two treatment regimens could reduce blood glucose level,TCM syndrome scores and PSQI scores,but the treatment group was significantly better than the control group in improving TCM symptoms
作者
刘婉文
曾纪斌
曾钰皓
LIU Wanwen;ZENG Jibin;ZENG Yuhao(Baoan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518101,Guangdong,China;Guangdong Pharmaceutical University,Yunfu 527300,Guangdong,China)
出处
《辽宁中医药大学学报》
CAS
2019年第5期194-197,共4页
Journal of Liaoning University of Traditional Chinese Medicine
