摘要
目的宫颈癌是女性常见的妇科肿瘤之一,复发性宫颈癌的治疗具有很大的难度,也是临床急需解决的问题。本研究对比单纯放疗和同步放化疗治疗复发性宫颈癌的临床效果,探讨同步放化疗对复发性宫颈癌的临床意义,筛选最佳治疗方法。方法选取2002-12-01-2012-12-01南阳市中心医院收治的110例复发性宫颈癌患者。根据患者治疗方式分为对照组(n=55)和研究组(n=55),对照组患者采用单纯放疗,研究组患者采用同步放化疗,观察两组患者治疗后的总有效率及并发症发生率,并统计各组1、3和5年生存率。结果对照组患者1年生存率为45.5%(25/55),与研究组的61.8%(34/55)相比,差异无统计学意义,χ~2=2.961,P=0.085;对照组患者3年生存率为30.9%(25/55),与研究组的58.2%(32/55)相比,差异有统计学意义,χ~2=8.28,P=0.004;对照组患者5年生存率为14.6%(8/55),与研究组的36.4%(20/55)相比,差异有统计学意义,χ~2=6.899,P=0.009。对照组患者出现消化道反应、胃肠道反应、骨髓抑制及肝肾损伤情况与研究组比较差异均无统计学意义,均P>0.05。对照组并发症发生率为65.5%(36/55),与研究组的69.1%(38/55)比较,差异无统计学意义,χ~2=0.165,P=0.684。结论同步放化疗治疗复发性宫颈癌临床疗效优于单纯放疗,值得临床推广应用。
OBJECTIVE Cervical cancer is one of the common gynecological tumors in women.The treatment of recurrent cervical cancer is very difficult,and it is also an urgent problem to be solved.This study aimed to select the optimal treatment for recurrent cervical cancer,we compared the clinical efficacy of radiotherapy alone and concurrent chemoradiotherapy in the treatment of recurrent cervical cancer and investigated the clinical significance of concurrent chemoradiotherapy for recurrent cervical cancer.METHODS A total of 110patients with recurrent cervical cancer admitted to the Center Hospital of Nanyang City of Henan Province from December 1,2002to December 1,2012were selected.According to the treatments methods,they were divided into study group(n=55)and control group(n=55).The patients from control group received radiotherapy alone,while the patients from study group received concurrent chemoradiotherapy.The total effective rate and incidence of complication were observed after treatment.The one-,three-,five-year survival rate of each group was investigated.RESULTS The 1-year survival rates of control group and study group were 45.5%and61.8%(χ^2=2.961,P=0.085).The 3-year survival rates of control group and study group were 30.9%and 58.2%(χ^2=8.28,P=0.004).The 5-year survival rates of control group and study group were 14.6%and 36.4%(χ^2=6.899,P=0.009).There was no difference in the incidence of complications between the study group(69.1%)and the control group(65.5%),which was not statistically significant(χ^2=0.165,P=0.684).CONCLUSIONS The clinical efficacy of concurrent chemoradiotherapy for recurrent cervical cancer is better than radiotherapy alone.It is worthy of promoting in clinic.
作者
王文廉
屈中玉
赵国强
WANG Wen-lian;QU Zhong-yu;ZHAO Guo-qiang(Firstward of Oncology Department,Center Hospital of Nanyang City,Nanyang 473000,P.R.China;Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,P.R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2019年第8期570-572,587,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
单纯放疗
同步放化疗
复发性宫颈癌
临床疗效
radiotherapy alone
concurrent chemoradiotherapy
recurrent cervical cancer
clinical efficacy
