摘要
目的评估利伐沙班与低分子肝素(LMWH)在恶性肿瘤并发静脉血栓栓塞症(VTE)患者中抗凝治疗的有效性与安全性。方法选取2016年1月至2017年6月连续入住山西医学科学院山西大医院血管外科的恶性肿瘤并发急性VTE患者99例,分别采用利伐沙班与LMWH对患者进行抗凝治疗,其中利伐沙班组43例,低分子肝素组56例。出院后随访1年,观察患者的疗效以及在治疗过程中有无出血、复发及死亡,并采用Kaplan-Meier生存曲线评价2种治疗方法的安全性。结果低分子肝素组患者抗凝总有效例数、复发例数、出血例数及死亡例数分别为50例(89%)、7例(13%)、6例(11%)及4例(7%),利伐沙班组为37例(86%)、6例(14%)、4例(9%)及5例(12%),2组间总有效率、复发率、出血率及全因死亡率差异均无统计学意义(P>0.05)。结论低分子肝素与利伐沙班对恶性肿瘤并发VTE的患者进行抗凝治疗时具有相似的疗效与安全性。
Objective To evaluate the efficacy and safety of rivaroxaban and low-molecular weight heparin(LMWH) in the treatment of malignant tumors complicated with venous thromboembolism(VTE). Methods A prospective study was conducted. A total of 99 patients with malignant tumor complicated with acute VTE admitted to the Department of Vascular Surgery, Shanxi Dayi Hospital(Shanxi Academy of Medical Sciences) between January2016 and June 2017 were included in the study. All patients were treated with rivaroxaban(n=43) and LMWH(n=56)for anticoagulant therapy, respectively. Followed up for 1 year after discharge, the patients were observed for the effect and incidence of bleeding, recurrence and death during the treatment. Kaplan-Meier survival curves were used to evaluate the safety of the two treatments. Results The numbers of effective anticoagulation, recurrence, bleeding and death in the LMWH group were 50(89%), 7(13%), 6(11%) and 4(7%), and those in the rivaroxaban group were 37(86%), 6(14%), 4(9%) and 5(12%), respectively. There were no statistically significant differences in the total effec-tive rate(P=0.657), recurrence rate(P=0.865), bleeding rate(P=0.814) and all-cause mortality(P=0.452) between the two groups. Conclusion LMWH and rivaroxaban show similar efficacy and safety in anticoagulant therapy for patients with malignant tumor complicated with VTE.
作者
张建陶
赵斌亮
郝斌
杨涛
Zhang Jiantao;Zhao Binliang;Hao Bin;Yang Tao(Department of Vascular Surgery,Shanxi Academy of Medical Sciences,Shanxi Dayi Hospital,Taiyuan 030032,China)
出处
《中国药物与临床》
CAS
2019年第9期1410-1413,共4页
Chinese Remedies & Clinics
基金
山西省软科学项目(2015041035-3)
关键词
肝素
低分子量
癌
静脉血栓栓塞
利伐沙班
Heparin,low-molecuar-weight
Carcinona
Venous thromboembolism
Rivaroxaban
