摘要
目的探究骨形态发生蛋白7(BMP-7)与急性脑梗死(ACI)患者的病情严重程度及预后的关系。方法 2017 年9 月至2018 年3 月收集105 例ACI患者(ACI组)及同期105 例来院就诊的健康体检者(对照组),检测血清BMP-7 水平,同时统计所有入组者的相关临床资料。对ACI 组患者随访3 个月并进行改良Rankin 量表(mRS)评分。对比ACI 组和健康对照组BMP-7 水平的差异,以及观察ACI 组BMP-7 水平与病情严重程度及预后的关系。结果 ACI 组患者的BMP-7 水平低于对照组,Logistic 回归结果显示吸烟、高血压、胱抑素C、糖化血红蛋白、BMP-7 水平等均与ACI 的发病密切相关(P < 0.05)。ACI患者中轻症组的BMP-7水平61.54(58.46,66.32)pg/ml高于重症组54.69(51.18,58.27)pg/ml。且BMP-7水平与 ACI组患者的NIHSS评分呈负相关(r=-0.702,P<0.05)。ACI患者中预后不良组BMP-7的水平低于预后良好组(P<0.05)。BMP-7水平与ACI患者的mRS评分呈负相关(r=-0.493,P<0.05)。结论 BMP-7 是ACI发病的影响因素,且BMP-7水平可用于评价ACI患者病情的严重程度及预测急性脑梗死患者的预后。
Objective To investigate the relationship between bone morphogenetic protein-7(BMP-7) level and the severity and prognosis of patients with acute cerebral infarction(ACI).Methods A total of 105 patients with ACI(ACI group) and 105 healthy people(control group) were recruited from September 2017 to March 2018.The serum BMP-7 level was measured and the clinical data of all patients were recorded.The patients in ACI group were followed up for 3 months and their Modified Rankin Scores(mRS) were recorded.The difference of BMP-7 level in ACI group and healthy control group,and the relationship between BMP-7 level and severity and prognosis in ACI group were observed.Results The level of BMP-7 in ACI group was lower than that in the control group.The result of Logistic regression showed that smoking,hypertension,diabetes,coronary heart disease,cystatin C,glycosylated hemoglobin,and BMP-7 levels are closely related to the incidence of ACI(P < 0.05).The level of BMP-7 in less severe ACI group was 61.54(58.46,66.32),which was higher than that in severe group 54.69(51.18,58.27).The level of BMP-7 was negatively correlated with the score of the National Institutes of Health Stroke Scale(NIHSS)(r=-0.702,P < 0.05).The level of BMP-7 in patients with poor prognosis was lower than that in patients with good prognosis(P < 0.05).There was a negative correlation between the level of BMP-7 and mRS score of ACI patients(r=-0.493,P< 0.05).Conclusions BMP-7 is an influential factor in the pathogenesis of ACI,and the level of BMP-7 can be used to evaluate the severity of ACI and predict the prognosis of patients with ACI.
作者
康凯
佡剑非
Kang Kai;Nao Jianfei(Department of Neurology,Shengjing Hospital,China Medical University,Shenyang,110004,China)
出处
《神经疾病与精神卫生》
2019年第3期282-286,共5页
Journal of Neuroscience and Mental Health
基金
2012年辽宁省第一批科学技术计划项目(2012225021).
关键词
脑梗死
骨形态发生蛋白质类
神经功能缺损
预后
Brain infarction
Bone morphogenetic proteins
Nerve function defect
Prognosis
